M
Michael Karin
Researcher at University of California, San Diego
Publications - 753
Citations - 246120
Michael Karin is an academic researcher from University of California, San Diego. The author has contributed to research in topics: IκB kinase & Signal transduction. The author has an hindex of 236, co-authored 704 publications receiving 226485 citations. Previous affiliations of Michael Karin include Sanford-Burnham Institute for Medical Research & University of California, Los Angeles.
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FBP1 is a nonenzymatic safety valve that curtails AKT activation to prevent insulin hyperresponsiveness
Lixiang Gu,Yahui Zhu,Kosuke Watari,Maiya Lee,Junlai Liu,Sofia Perez,Melinda Thai,Joshua Mayfield,Bichen Zhang,Karina Cunha e Rocha,Fuming Li,Laura C. Kim,Alexander Jones,Igor H. Wierzbicki,Xiao Liu,Alexandra C. Newton,Tatiana Kisseleva,Jun Hee Lee,Wei-hua Ying,David Gonzalez,Alan R. Saltiel,M. Celeste Simon,Michael Karin +22 more
TL;DR: In this paper , a human FBP1 deficiency does not cause hypoglycemia unless accompanied by fasting or starvation, which also trigger paradoxical hepatomegaly, hepatosteatosis, and hyperlipidemia in affected individuals.
Patent
Inhibition of B-cell maturation and antibody production
TL;DR: In this article, the authors present methods and compositions for the inhibition of B-cell maturation and antibody production without interfering with innate or T-cell mediated immunity. But they do not consider the effects of T-cells on B-cells.
Patent
Methods for treating castration resistant prostate cancer and metastasis by reducing B-cell number and/or function
TL;DR: In this paper, a method for reducing growth and/or metastasis of androgen-independent (castration resistant) prostate cancer in a tissue in an animal was proposed, which consisted of administering to the animal a therapeutically effective amount of a compound that reduced the number of B cells, and or the function of b cells, in the tissue.
Journal ArticleDOI
Tu1374: THERAPIES TARGETING MAST CELLS ARE EFFECTIVE IN IBS TREATMENT: A SYSTEMATIC REVIEW AND META-ANALYSIS
Patent
Method for detecting the presence of prostate cancer
Michael Karin,Jun-li Luo,Wei Tan +2 more
TL;DR: In this paper, the authors present compositions and methods for targeting the nuclear translocation of IkB kinase-α (IKKα) and the IKKα-mediated suppression of Maspin expression observed in metastatic prostate cancer cells.