M
Michael Karin
Researcher at University of California, San Diego
Publications - 753
Citations - 246120
Michael Karin is an academic researcher from University of California, San Diego. The author has contributed to research in topics: IκB kinase & Signal transduction. The author has an hindex of 236, co-authored 704 publications receiving 226485 citations. Previous affiliations of Michael Karin include Sanford-Burnham Institute for Medical Research & University of California, Los Angeles.
Papers
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Journal ArticleDOI
Regulation of antitumor immunity by inflammation-induced epigenetic alterations.
Michael Karin,Shabnam Shalapour +1 more
TL;DR: In this paper, the role of inflammation in initiating epigenetic alterations in immune cells, cancer-associated fibroblasts, and cancer cells was discussed and how and when epigenetic interventions can be combined with immunotherapies to improve therapeutic outcomes.
Journal ArticleDOI
IKKβ in intestinal epithelial cells regulates allergen-specific IgA and allergic inflammation at distant mucosal sites
Astrid Bonnegarde-Bernard,Junbae Jee,Michael J. Fial,Famke Aeffner,Estelle Cormet-Boyaka,Ian C. Davis,Mingqun Lin,Daniel Tomé,Michael Karin,Yan Sun,Prosper N. Boyaka +10 more
TL;DR: It is shown that IKKβ in IECs shapes the gut microbiota and immune responses to ingested antigens and influences allergic responses in the airways via regulation of IgA Ab responses.
Journal ArticleDOI
Role for IKK2 in muscle: waste not, want not.
TL;DR: Show that muscle-specific disruption in mice of the gene encoding IKK2 prevents NF-kappaB activation in response to denervation or toxin-induced injury, providing strong evidence in support of a major pathogenic role for inflammation in a variety of muscular dystrophies characterized by progressive muscle fiber degeneration.
Book ChapterDOI
Immunoregulatory Genes and Immunosuppression by Glucocorticoids
TL;DR: Glucocorticoids are physiological inhibitors of inflammatory responses and are widely used as immunosuppressive and anti-inflammatory agents but the molecular mechanisms that underlie their therapeutic effects are poorly understood.
Journal ArticleDOI
The neglected brothers come of age: B cells and cancer.
Shabnam Shalapour,Michael Karin +1 more
TL;DR: The role of B cells and their subtypes in suppressing or supporting cancer initiation, progression, metastasis and response to therapy has been long debated as mentioned in this paper, perhaps partially due to their heterogeneity and range of actions.