M
Michael Karin
Researcher at University of California, San Diego
Publications - 753
Citations - 246120
Michael Karin is an academic researcher from University of California, San Diego. The author has contributed to research in topics: IκB kinase & Signal transduction. The author has an hindex of 236, co-authored 704 publications receiving 226485 citations. Previous affiliations of Michael Karin include Sanford-Burnham Institute for Medical Research & University of California, Los Angeles.
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Journal ArticleDOI
Pas de Deux: Control of Anti-tumor Immunity by Cancer-Associated Inflammation
Shabnam Shalapour,Michael Karin +1 more
TL;DR: The future of cancer immunotherapy and its utility depend on improved understanding of the intricate dialog between cancer-associated inflammation and anti-tumor immunity and the ability to manipulate them in a predictable and beneficial manner.
Journal Article
The NF-kappa B activation pathway: its regulation and role in inflammation and cell survival.
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Tumor infiltrating B-cells are increased in prostate cancer tissue.
Jason Woo,Michael A. Liss,Michelle Muldong,Kerrin Palazzi,Amy Strasner,Massimo Ammirante,Nissi Varki,Ahmed Shabaik,Stephen H. Howell,Christopher J. Kane,Michael Karin,Christina Jamieson +11 more
TL;DR: New method to measure B-cells using computer-assisted digitized image analysis shows that higher B-cell infiltration was present within the intra-tumoral PCa regions compared to the extra-Tumoral benign prostate tissue regions in prostatectomy sections.
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A gradient of cactus protein degradation establishes dorsoventral polarity in the Drosophila embryo.
TL;DR: It is concluded that dorsoventral signaling results in a Cactus concentration gradient and proposed that signal-dependent phosphorylation directs the spatially regulated proteolysis of Cactus protein.
Journal ArticleDOI
TAK1-mediated autophagy and fatty acid oxidation prevent hepatosteatosis and tumorigenesis
Sayaka Inokuchi-Shimizu,Eek Joong Park,Yoon Seok Roh,Ling Yang,Ling Yang,Bi Zhang,Jingyi Song,Shuang Liang,Michael Pimienta,Koji Taniguchi,Xuefeng Wu,Kinji Asahina,William S. Lagakos,Mason R. Mackey,Shizuo Akira,Mark H. Ellisman,Dorothy D. Sears,Jerrold M. Olefsky,Michael Karin,David A. Brenner,Ekihiro Seki +20 more
TL;DR: Data indicate that TAK1 regulates hepatic lipid metabolism and tumorigenesis via the AMPK/mTORC1 axis, affecting both autophagy and PPARα activity.