M
Michael Karin
Researcher at University of California, San Diego
Publications - 753
Citations - 246120
Michael Karin is an academic researcher from University of California, San Diego. The author has contributed to research in topics: IκB kinase & Signal transduction. The author has an hindex of 236, co-authored 704 publications receiving 226485 citations. Previous affiliations of Michael Karin include Sanford-Burnham Institute for Medical Research & University of California, Los Angeles.
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Journal ArticleDOI
Signaling Pathways and Genes that Inhibit Pathogen-Induced Macrophage Apoptosis— CREB and NF-κB as Key Regulators
Jin Mo Park,Florian R. Greten,Athena Wong,Randal J. Westrick,J. Simon C. Arthur,Kinya Otsu,Alexander Hoffmann,Marc Montminy,Michael Karin +8 more
TL;DR: Key roles for transcription factor CREB, a target for p38 signaling, and the plasminogen activator 2 (PAI-2) gene, aTarget genes whose products prevent TLR4-induced apoptosis and a p38-dependent transcription factor required for their induction are described.
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p62 in Cancer: Signaling Adaptor Beyond Autophagy
TL;DR: New evidence supports an autophagy-independent key role of the adaptor p62 (encoded by the gene Sqstm1) in signaling functions central to tumor initiation in the epithelium and suppression of tumor progression in the stroma.
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MEK kinase 1 is critically required for c-Jun N-terminal kinase activation by proinflammatory stimuli and growth factor-induced cell migration.
TL;DR: Using MEKK1-deficient embryonic stem cells prepared by gene targeting, the function of the MAP3K MEK kinase 1 (MEKK1) in proinflammatory signaling is examined and it is found that it is required for JNK activation by diverse proinflammatory stimuli, including tumor necrosis factor alpha, IL-1, double-stranded RNA, and lipopolysaccharide.
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Obesity and Cancer: The Oil that Feeds the Flame
TL;DR: Recent advances in understanding how obesity increases cancer risk are discussed and a unifying hypothesis according to which the major tumor-promoting mechanism triggered by hypernutrition is the indolent inflammation that takes place at particular organ sites, including liver, pancreas, and gastrointestinal tract is proposed.
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NF-κB and cancer : Mechanisms and targets
TL;DR: NF‐κB and the signaling pathways that mediate its activation have become attractive targets for development of new chemopreventive and chemotherapeutic approaches.