M
Michael Karin
Researcher at University of California, San Diego
Publications - 753
Citations - 246120
Michael Karin is an academic researcher from University of California, San Diego. The author has contributed to research in topics: IκB kinase & Signal transduction. The author has an hindex of 236, co-authored 704 publications receiving 226485 citations. Previous affiliations of Michael Karin include Sanford-Burnham Institute for Medical Research & University of California, Los Angeles.
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Journal ArticleDOI
Activation of activating protein 1 during hepatic acute phase response
Masahira Hattori,Antonio Tugores,J. K. Westwick,Linda Veloz,Hyam L. Leffert,Michael Karin,David A. Brenner +6 more
TL;DR: The complexity of AP-1 hepatic transcription factor responses to humoral regulators with direct hepatocellular effects is demonstrated to demonstrate the coordinated regulation of many genes.
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Opposing roles of hepatic stellate cell subpopulations in hepatocarcinogenesis
Aveline Filliol,Yoshinobu Saito,Ajay Nair,Dianne H. Dapito,Le-Xing Yu,Aashreya Ravichandra,Sonakshi Bhattacharjee,Silvia Affo,Naoto Fujiwara,H. Irene Su,Qi-Lun Sun,Thomas Savage,John R. Wilson-Kanamori,Jorge Matias Caviglia,Likang Chin,Dongning Chen,Xiaobo Wang,Stefano Caruso,Jin-Ku Kang,Amit Dipak Amin,Sebastian Wallace,Ross Dobie,D. Yin,Oscar M Rodriguez-Fiallos,Chuan Yin,Adam Mehal,Benjamin Izar,Richard A. Friedman,Rebecca G. Wells,Utpal B. Pajvani,Yujin Hoshida,Helen Remotti,Nicholas Arpaia,Jessica Zucman-Rossi,Michael Karin,Neil C. Henderson,Ira Tabas,Robert F. Schwabe +37 more
TL;DR: In this article , the authors investigated the role of hepatic stellate cells (HSCs) in hepatocellular carcinoma (HCC) development and showed that an increased imbalance between cytokine-producing and myofibroblastic HSCs during liver disease progression was associated with increased HCC risk.
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Mutations in the conserved C-terminal sequence in thyroid hormone receptor dissociate hormone-dependent activation from interference with AP-1 activity.
Fahri Saatcioglu,Gabriela N. Lopez,Brian L. West,Ebrahim Zandi,Weijun Feng,Haiping Lu,Ali Esmaili,James W. Apriletti,Peter J. Kushner,John D. Baxter,Michael Karin +10 more
TL;DR: The C-terminal conserved region of T3R alpha contains a recognition surface for GRIP1 or a similar coactivator that facilitates its interaction with the basal transcriptional apparatus, which is important for ligand-dependent transactivation.
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Regulation of late B cell differentiation by intrinsic IKKα-dependent signals
TL;DR: It is found that IKKαAA B cells mount normal primary antibody responses but do not enter germinal centers, suggesting that the NIK–IKKα–p52 axis is not as linear and exclusive as previous studies suggest, and IKK α possesses critical NF-κB-independent functions in B cells.
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Differential Regulation of Hepatic Transporters in the Absence of Tumor Necrosis Factor-α, Interleukin-1β, Interleukin-6, and Nuclear Factor-κB in Two Models of Cholestasis
TL;DR: Assessment of the role of cytokines and nuclear factor-κB in the transcriptional regulation of transporters in two models of cholestasis, lipopolysaccharide (LPS) administration and bile duct ligation concluded that disparities are not due to the individual activity of TNF-α, IL-1,IL-6, or NF-κBs but to the differences in the mechanism of choledestasis.