M
Michael Karin
Researcher at University of California, San Diego
Publications - 753
Citations - 246120
Michael Karin is an academic researcher from University of California, San Diego. The author has contributed to research in topics: IκB kinase & Signal transduction. The author has an hindex of 236, co-authored 704 publications receiving 226485 citations. Previous affiliations of Michael Karin include Sanford-Burnham Institute for Medical Research & University of California, Los Angeles.
Papers
More filters
Journal ArticleDOI
Casein kinase II is a negative regulator of c-Jun DNA binding and AP-1 activity.
Anning Lin,Jeffrey A. Frost,Tiliang Deng,Tod Smeal,Nadia Al-Alawi,Ushio Kikkawa,Tony Hunter,David A. Brenner,Michael Karin +8 more
TL;DR: One of the roles of CKII, a major nuclear protein kinase with no known functions, is to attenuate AP-1 activity through phosphorylation of c-Jun, a phosphoprotein in nonstimulated fibroblasts and epithelial cells.
Journal ArticleDOI
c-Fos transcriptional activity stimulated by H-Ras-activated protein kinase distinct from JNK and ERK
Tiliang Deng,Michael Karin +1 more
TL;DR: RAS proteins exert their mitogenic and oncogenic effects through activation of downstream protein kinases, and at least three types of proline-directed kinases transmit Ras- and mitogen-generated signals to the transcriptional machinery.
Journal ArticleDOI
Stabilization of interleukin-2 mRNA by the c-Jun NH2-terminal kinase pathway.
TL;DR: Signaling pathways that stabilize interleukin-2 (IL-2) messenger RNA (mRNA) in activated T cells were examined and multiple elements within IL-2 mRNA modulate its stability in a combinatorial manner.
Journal ArticleDOI
Control of transcription factors by signal transduction pathways: the beginning of the end.
Michael Karin,Tod Smeal +1 more
TL;DR: The mechanisms that control the activity of two groups of sequence-specific transcription factors, the AP-1 and CREB/ATF proteins, are described and serve as a paradigm explaining the transfer of regulatory information from the cell surface to the nucleus.
Journal ArticleDOI
Three distinct signalling responses by murine fibroblasts to genotoxic stress
Zheng-gang Liu,R. Baskaran,Elaine T. Lea-Chou,Lauren D. Wood,Yan Chen,Michael Karin,Jean Y. J. Wang +6 more
TL;DR: Findings show that signals generated by genotoxins are transduced by multiple, independent pathways, and only p53 appears to be a universal sensor of genotoxic stress.