M
Michael Karin
Researcher at University of California, San Diego
Publications - 753
Citations - 246120
Michael Karin is an academic researcher from University of California, San Diego. The author has contributed to research in topics: IκB kinase & Signal transduction. The author has an hindex of 236, co-authored 704 publications receiving 226485 citations. Previous affiliations of Michael Karin include Sanford-Burnham Institute for Medical Research & University of California, Los Angeles.
Papers
More filters
Journal ArticleDOI
IκB kinaseα/β control biliary homeostasis and hepatocarcinogenesis in mice by phosphorylating the cell-death mediator receptor-interacting protein kinase 1.
Christiane Koppe,Patricia Verheugd,Jérémie Gautheron,Florian Reisinger,Karina Kreggenwinkel,Christoph Roderburg,Luca Quagliata,Luigi Terracciano,Nikolaus Gassler,Rene Tolba,Yannick Boege,Achim Weber,Michael Karin,Mark Luedde,Ulf P. Neumann,Ralf Weiskirchen,Frank Tacke,Mihael Vucur,Christian Trautwein,Bernhard Lüscher,Christian Preisinger,Mathias Heikenwalder,Tom Luedde +22 more
TL;DR: IKK‐complex subunits transmit a previously unrecognized signal through RIPK1, which is fundamental for the long‐term consequences of chronic hepatic inflammation and might have potential implications for future pharmacological strategies against cholestatic liver disease and cancer.
Journal ArticleDOI
Induction of human growth hormone promoter activity by the adenosine 3',5'-monophosphate pathway involves a novel responsive element.
Sharon Dana,Michael Karin +1 more
TL;DR: Results suggest that a novel cAMP-responsive element exists within 82 basepairs upstream from the transcriptional start of the hGH gene and that hGH regulation by GRF may involve interaction between a tissue-specific element and a cAMP -inducible element.
Journal ArticleDOI
Nod2 mediates susceptibility to Yersinia pseudotuberculosis in mice
Ulrich Meinzer,Ulrich Meinzer,Sophie Esmiol-Welterlin,Sophie Esmiol-Welterlin,Frédérick Barreau,Dominique Berrebi,Monique Dussaillant,Stéphane Bonacorsi,Fabrice Chareyre,Michiko Niwa-Kawakita,Corinne Alberti,Ghislaine Sterkers,Claude Villard,Thécla Lesuffleur,Michel Peuchmaur,Michael Karin,Lars Eckmann,Marco Giovannini,Vincent Ollendorff,Vincent Ollendorff,Hans Wolf-Watz,Jean-Pierre Hugot +21 more
TL;DR: It is concluded that Nod2 contributes to the susceptibility to Y. pseudotuberculosis in mice and this resistance phenotype was lost in case of intraperitoneal infection.
Journal ArticleDOI
Disruption of JNK2 Decreases the Cytokine Response to Plasmodium falciparum Glycosylphosphatidylinositol In Vitro and Confers Protection in a Cerebral Malaria Model
Ziyue Lu,Lena Serghides,Samir N. Patel,Norbert Degousee,Barry B. Rubin,Gowdahali Krishnegowda,D. Channe Gowda,Michael Karin,Kevin C. Kain,Kevin C. Kain +9 more
TL;DR: It is demonstrated that ERK1/2, JNK, p38, c-Jun, and activating transcription factor-2 became phosphorylated in pfGPI-stimulated macrophages, and suggested that JNK2 is a potential target for therapeutic interventions in severe malaria.
Journal ArticleDOI
Proteotyping of mammary tissue from transgenic and gene knockout mice with immunohistochemical markers: a tool to define developmental lesions.
Jonathan M. Shillingford,Keiko Miyoshi,Gertraud W. Robinson,Brian Bierie,Yixue Cao,Michael Karin,Lothar Hennighausen +6 more
TL;DR: It is proposed that the technique of proteotyping will have wide applications in the analyses of defects in other mouse models and its use in the elucidation of specific developmental lesions is proposed.