https://cancerbiologyprogram.med.wayne.edu/pdfs/hallmarks_cancer_article.pdf

Hallmarks of cancer: the next generation.

抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1（PfPMP1）与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员，通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A

https://staff.blog.ui.ac.id/hsuryadi/files/2012/02/ROS_RNS.pdf

Free radicals and antioxidants in normal physiological functions and human disease

Pathogen Recognition and Innate Immunity

Several reactive oxygen species (ROS) are continuously produced in plants as byproducts of aerobic metabolism. Depending on the nature of the ROS species, some are highly toxic and rapidly detoxified by various cellular enzymatic and nonenzymatic mechanisms. Whereas plants are surfeited with mechanisms to combat increased ROS levels during abiotic stress conditions, in other circumstances plants appear to purposefully generate ROS as signaling molecules to control various processes including pathogen defense, programmed cell death, and stomatal behavior. This review describes the mechanisms of ROS generation and removal in plants during development and under biotic and abiotic stress conditions. New insights into the complexity and roles that ROS play in plants have come from genetic analyses of ROS detoxifying and signaling mutants. Considering recent ROS-induced genome-wide expression analyses, the possible functions and mechanisms for ROS sensing and signaling in plants are compared with those in animals and yeast.

REACTIVE OXYGEN SPECIES: Metabolism, Oxidative Stress, and Signal Transduction

Epithelial cell-intrinsic IKKbeta expression regulates innate and adaptive immunity in the gut

BAFF Accelerates Development of Chronic Lymphocytic Leukemia in TCL1 Transgenic Mice.

Up to 20% of cancers arise from chronic inflammation and persistent infections. Moreover, most solid tumors contain immune infiltrates. Tumor-associated inflammatory cells play broad roles in differen

Innate Immunity, Inflammation and Colorectal Cancer

Current approaches to staging chronic liver diseases have limited utility for predicting liver cancer risk. Here, we employed single-nucleus RNA sequencing (snRNA-seq) to characterize the cellular microenvironment of healthy and pre-malignant livers using two distinct mouse models. Downstream analyses unraveled a previously uncharacterized disease-associated hepatocyte (daHep) transcriptional state. These cells were absent in healthy livers but increasingly prevalent as chronic liver disease progressed. Copy number variation (CNV) analysis of microdissected tissue demonstrated that daHep-enriched regions are riddled with structural variants, suggesting these cells represent a pre-malignant intermediary. Integrated analysis of three recent human snRNA-seq datasets confirmed the presence of a similar phenotype in human chronic liver disease and further supported its enhanced mutational burden. Importantly, we show that high daHep levels precede carcinogenesis and predict a higher risk of hepatocellular carcinoma development. These findings may change the way chronic liver disease patients are staged, surveilled, and risk stratified. 

https://doi.org/10.1016/j.xgen.2023.100301

Single-nucleus RNA sequencing of pre-malignant liver reveals disease-associated hepatocyte state with HCC prognostic potential

Preface.- Understanding the Logic of IkappaB:NF-kappaB Regulation in Structural Terms.- NF-kappaB/Rel proteins and the humoral immune responses of Drosophila melanogaster.- Specialized chromatin patterns in the control of inflammatory gene expression.- IKK regulation and human genetics.- Control of NF-kappaB activity by proteolysis.- NF-kappaB and Innate Immunity.- NF-kappaB and mucosal homeostasis.- IKK and NF-kappaB mediated functions in carcinogenesis.- Macrophages and NF-kappaB in Cancer.- NF-kappaB in liver cancer - the plot thickens.- NF-kappaB as a target for oncogenic viruses.- Inhibition of NF-kappaB signaling as a strategy in disease therapy.- Subject index

Michael Karin

Papers

Epithelial cell-intrinsic IKKbeta expression regulates innate and adaptive immunity in the gut

BAFF Accelerates Development of Chronic Lymphocytic Leukemia in TCL1 Transgenic Mice.

Innate Immunity, Inflammation and Colorectal Cancer

Single-nucleus RNA sequencing of pre-malignant liver reveals disease-associated hepatocyte state with HCC prognostic potential

NF-κB in health and disease