M
Michael Karin
Researcher at University of California, San Diego
Publications - 753
Citations - 246120
Michael Karin is an academic researcher from University of California, San Diego. The author has contributed to research in topics: IκB kinase & Signal transduction. The author has an hindex of 236, co-authored 704 publications receiving 226485 citations. Previous affiliations of Michael Karin include Sanford-Burnham Institute for Medical Research & University of California, Los Angeles.
Papers
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Patent
Methods for identifying and using IKK inhibitors
Michael Karin,Pankaj Kapahi +1 more
TL;DR: In this paper, the authors provide methods and compositions for inhibiting IKK and COX2, as well as identifying compounds with activity as inhibitors of IKK, and for the treatment of diseases and conditions wherein IKK is implicated and inhibition of its activity is desired.
Journal ArticleDOI
Inactivation of IκB-kinase-β dependent genes in airway epithelium reduces tobacco smoke induced acute airway inflammation
TL;DR: An important role for NF-kappaB regulated genes in airway epithelium in contributing to acute tobacco smoke induced airway inflammation not only in the peribronchial space but also in the alveolar space is demonstrated.
Journal ArticleDOI
Signaling cascades and inflammasome activationin microbial infections
TL;DR: This review analyzes the current knowledge regarding association of innate immune signaling pathways with inflammasome activation in response to bacterial infection and recognizes recognition of extracellular pathogenassociated molecular patterns by pattern recognition receptors (PRRs) results in activation of host defense signaling pathways.
Journal ArticleDOI
Intermittent hypoxia and hypercapnia induces inhibitor of nuclear factor-κB kinase subunit β-dependent atherosclerosis in pulmonary arteries.
Toshihiro Imamura,Jin Xue,Orit Poulsen,Dan Zhou,Michael Karin,Gabriel G. Haddad,Gabriel G. Haddad +6 more
TL;DR: IKKβ-dependent NF-kappa B activity in myeloid-lineage cells plays a critical role in IHH-induced PA atherosclerosis at the early stage, and both IKKβ deletion and IHH have no effects on Atherosclerosis in the aorta.
Journal ArticleDOI
IκB kinase β (IKKβ) does not mediate feedback inhibition of the insulin signalling cascade.
Graeme I. Lancaster,Beata Skiba,Christine Yang,Hayley T. Nicholls,Katherine G. Langley,M. H. Stanley Chan,Clinton R. Bruce,Gordon W. Rewcastle,Peter R. Shepherd,Michael Karin,Mark A. Febbraio +10 more
TL;DR: The findings that IKKβ, although activated by insulin, does not promote direct serine phosphorylation of IRS1 and does not contribute to the feedback inhibition of the insulin signalling cascade are confirmed.