M
Michael Karin
Researcher at University of California, San Diego
Publications - 753
Citations - 246120
Michael Karin is an academic researcher from University of California, San Diego. The author has contributed to research in topics: IκB kinase & Signal transduction. The author has an hindex of 236, co-authored 704 publications receiving 226485 citations. Previous affiliations of Michael Karin include Sanford-Burnham Institute for Medical Research & University of California, Los Angeles.
Papers
More filters
Journal ArticleDOI
p38 and Extracellular Signal-Regulated Kinases Regulate the Myogenic Program at Multiple Steps
Zhenguo Wu,Pamela J. Woodring,Kunjan S Bhakta,Kumiko Tamura,Fang Wen,James R. Feramisco,Michael Karin,Jean Y. J. Wang,Pier Lorenzo Puri +8 more
TL;DR: Investigation of the role of two MAPKs, p38 and extracellular signal-regulated kinase (ERK), whose activities undergo significant changes during muscle differentiation finds p38 is rapidly activated in myocytes induced to differentiate and ERK shows a biphasic activation profile, with peaks of activity in undifferentiated myoblasts and postmitotic myotubes.
Journal ArticleDOI
Isolation of an AP-1 repressor by a novel method for detecting protein-protein interactions.
TL;DR: A novel screen for detecting protein-protein interactions that is not based on a transcriptional readout is developed and one of these, JDP2, heterodimerizes with c-Jun in nonstimulated cells and represses AP-1-mediated activation.
Journal ArticleDOI
Hepatocyte Necrosis Induced by Oxidative Stress and IL-1α Release Mediate Carcinogen-Induced Compensatory Proliferation and Liver Tumorigenesis
Toshiharu Sakurai,Guobin He,Atsushi Matsuzawa,Guann-Yi Yu,Shin Maeda,Gary Hardiman,Michael Karin +6 more
TL;DR: Hepatocyte-specific p38 alpha ablation enhanced ROS accumulation and liver damage, which were prevented upon administration of an antioxidant, and IL-1 alpha release by necrotic hepatocytes is therefore an important mediator of liver tumorigenesis.
Journal ArticleDOI
IKKα Provides an Essential Link between RANK Signaling and Cyclin D1 Expression during Mammary Gland Development
Yixue Cao,Giuseppina Bonizzi,Tiffany N. Seagroves,Florian R. Greten,Randall S. Johnson,Emmett V. Schmidt,Michael Karin +6 more
TL;DR: IKKα is a critical intermediate in a pathway that controls mammary epithelial proliferation in response to RANK signaling via cyclin D1 through NF-κB activation.
Journal ArticleDOI
Autophagy, Inflammation, and Immunity: A Troika Governing Cancer and Its Treatment
TL;DR: New studies indicate that, in addition to its cell-autonomous anti-tumorigenic functions, autophagy inhibits cancer development by orchestrating inflammation and immunity and should improve the efficacy of cancer immunotherapy.