M
Michael Karin
Researcher at University of California, San Diego
Publications - 753
Citations - 246120
Michael Karin is an academic researcher from University of California, San Diego. The author has contributed to research in topics: IκB kinase & Signal transduction. The author has an hindex of 236, co-authored 704 publications receiving 226485 citations. Previous affiliations of Michael Karin include Sanford-Burnham Institute for Medical Research & University of California, Los Angeles.
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Journal ArticleDOI
ER stress cooperates with hypernutrition to trigger TNF-dependent spontaneous HCC development
Hayato Nakagawa,Atsushi Umemura,Koji Taniguchi,Joan Font-Burgada,Debanjan Dhar,Hisanobu Ogata,Zhenyu Zhong,Mark A. Valasek,Ekihiro Seki,Juan Hidalgo,Kazuhiko Koike,Randal J. Kaufman,Michael Karin +12 more
TL;DR: Both NASH and HCC development were dependent on TNF produced by inflammatory macrophages that accumulate in the MUP-uPA liver in response to hepatocyte ER stress.
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Hybrid Periportal Hepatocytes Regenerate the Injured Liver without Giving Rise to Cancer.
Joan Font-Burgada,Shabnam Shalapour,Suvasini Ramaswamy,Brian Hsueh,David Rossell,Atsushi Umemura,Koji Taniguchi,Hayato Nakagawa,Mark A. Valasek,Li Ye,Janel L. Kopp,Maike Sander,Hannah Carter,Karl Deisseroth,Inder M. Verma,Michael Karin +15 more
TL;DR: A pre-existing population of periportal hepatocytes, located in the portal triads of healthy livers and expressing low amounts of Sox9 and other bile-duct-enriched genes, undergo extensive proliferation and replenish liver mass after chronic hepatocyte-depleting injuries and represent a unique way to restore tissue function and avoid tumorigenesis.
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Expanding TRAF function: TRAF3 as a tri-faced immune regulator
TL;DR: The current understanding of the role of TRAF3 in TNFR and TLR signalling pathways, and its role in disease is discussed.
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JNK1 is required for maintenance of neuronal microtubules and controls phosphorylation of microtubule-associated proteins.
TL;DR: It is found that a member of the c-Jun NH(2)-terminal protein kinase (JNK) subgroup of MAP kinases, JNK1, is involved in regulation of MT dynamics in neuronal cells.
Journal ArticleDOI
Distinct Roles for JNK1 and JNK2 in Regulating JNK Activity and c-Jun-Dependent Cell Proliferation
Kanaga Sabapathy,Konrad Hochedlinger,Shin Yuen Nam,Anton Bauer,Michael Karin,Erwin F. Wagner +5 more
TL;DR: It is found that Jnk2-/- fibroblasts exit G1 and enter S phase earlier than wild-type counterparts, while JnK1-/- cells show the inverse phenotype, and mechanistic insights into the distinct roles of different JNK isoforms are provided.