M
Michael Karin
Researcher at University of California, San Diego
Publications - 753
Citations - 246120
Michael Karin is an academic researcher from University of California, San Diego. The author has contributed to research in topics: IκB kinase & Signal transduction. The author has an hindex of 236, co-authored 704 publications receiving 226485 citations. Previous affiliations of Michael Karin include Sanford-Burnham Institute for Medical Research & University of California, Los Angeles.
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Journal ArticleDOI
Inhibition of NF-κB in cancer cells converts inflammation- induced tumor growth mediated by TNFα to TRAIL-mediated tumor regression
TL;DR: The role of NF-kappaB in inflammation-induced tumor growth is investigated in an experimental murine cancer metastasis model and it is found that LPS-induced metastatic growth response in this model depends on both TNFalpha production by host hematopoietic cells and NF- kappaB activation in tumor cells.
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Control of cell cycle progression by c-Jun is p53 dependent
Martin Schreiber,Andrea Kolbus,Fabrice Piu,Fabrice Piu,Axel Szabowski,Uta Möhle-Steinlein,Jianmin Tian,Michael Karin,Peter Angel,Erwin F. Wagner +9 more
TL;DR: It is demonstrated that fibroblasts derived from c-jun-/- mouse fetuses exhibit a severe proliferation defect and undergo a prolonged crisis before spontaneous immortalization, and a mechanistic link between c-Jun-dependent mitogenic signaling and cell-cycle regulation is established.
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Macrophage Expression of Hypoxia-Inducible Factor-1α Suppresses T-Cell Function and Promotes Tumor Progression
Andrew L. Doedens,Christian Stockmann,Mark P. Rubinstein,Debbie Liao,Na Zhang,David G. DeNardo,Lisa M. Coussens,Michael Karin,Ananda W. Goldrath,Randall S. Johnson +9 more
TL;DR: It is found that hypoxia powerfully augmented macrophage-mediated T-cell suppression in vitro in a manner dependent on macrophages expression of HIF-1α, which links the innate immune hypoxic response to tumor progression through induction of T- cell suppression in the tumor microenvironment.
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NF-kappaB is a negative regulator of IL-1beta secretion as revealed by genetic and pharmacological inhibition of IKKbeta.
Florian R. Greten,Florian R. Greten,Melek C. Arkan,Melek C. Arkan,Julia Bollrath,Li-Chung Hsu,Jason Goode,Cornelius Miething,Serkan Ismail Göktuna,Michael Neuenhahn,Joshua Fierer,Stephan Paxian,Nico van Rooijen,Yajun Xu,Timothy D. Ocain,Bruce Jaffee,Dirk H. Busch,Justus Duyster,Roland M. Schmid,Lars Eckmann,Michael Karin +20 more
TL;DR: An unanticipated role for IKKbeta-dependent NF-kappaB signaling in the negative control of IL-1beta production is unraveled and potential complications of long-term IKK beta inhibition are highlighted.
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Immunity, inflammation, and cancer: an eternal fight between good and evil
Shabnam Shalapour,Michael Karin +1 more
TL;DR: This antagonism between inflammation and immunity also affects the outcome of cancer treatment and needs to be considered when designing new therapeutic approaches.