M
Michael Karin
Researcher at University of California, San Diego
Publications - 753
Citations - 246120
Michael Karin is an academic researcher from University of California, San Diego. The author has contributed to research in topics: IκB kinase & Signal transduction. The author has an hindex of 236, co-authored 704 publications receiving 226485 citations. Previous affiliations of Michael Karin include Sanford-Burnham Institute for Medical Research & University of California, Los Angeles.
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Journal ArticleDOI
Conditional Deletion of IκB-Kinase-β Accelerates Helicobacter-Dependent Gastric Apoptosis, Proliferation, and Preneoplasia
Wataru Shibata,Shigeo Takaishi,Sureshkumar Muthupalani,D. Mark Pritchard,Mark T. Whary,Arlin B. Rogers,James G. Fox,Kelly S. Betz,Klaus H. Kaestner,Michael Karin,Timothy C. Wang +10 more
TL;DR: In this paper, the role of NF-κB pathway in gastric carcinogenesis and injury has not been well-defined, and a conditional knockout of IKKβ in Gastric epithelial cells (GECs) and myeloid cells, and examined responses to ionizing radiation (IR) and Helicobacter felis infection.
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p38α inhibits liver fibrogenesis and consequent hepatocarcinogenesis by curtailing accumulation of reactive oxygen species.
Toshiharu Sakurai,Masatoshi Kudo,Atsushi Umemura,Guobin He,Ahmed M. Elsharkawy,Ekihiro Seki,Michael Karin +6 more
TL;DR: P38α and its target HSP25/HSP27 appear to play a conserved and critical hepatoprotective function by curtailing ROS accumulation in liver parenchymal cells engaged in oxidative metabolism of exogenous chemicals.
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PKCλ/ι Loss Induces Autophagy, Oxidative Phosphorylation, and NRF2 to Promote Liver Cancer Progression.
Yotaro Kudo,Masayuki Sugimoto,Esperanza Arias,Hiroaki Kasashima,Thekla Cordes,Juan F. Linares,Angeles Duran,Angeles Duran,Yuki Nakanishi,Naoko Nakanishi,Antoine L’Hermitte,Alex Campos,Nadia Senni,Tarmo Rooslid,Lewis R. Roberts,Ana Maria Cuervo,Christian M. Metallo,Michael Karin,Maria T. Diaz-Meco,Maria T. Diaz-Meco,Jorge Moscat,Jorge Moscat +21 more
TL;DR: It is shown that protein kinase C (PKC) λ/ι loss in hepatocytes promotes autophagy and oxidative phosphorylation, which results in ROS generation, which through NRF2 drives HCC through cell-aut autonomous and non-autonomous mechanisms.
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The tumor suppressor activity of IKKα in stratified epithelia is exerted in part via the TGF-β antiproliferative pathway
Barbara Marinari,Francesca Moretti,Elisabetta Botti,Maria Laura Giustizieri,Pascal Descargues,Alessandro Giunta,Carmine Stolfi,Costanza Ballarò,Marina Papoutsaki,Stefano Alemà,Giovanni Monteleone,Sergio Chimenti,Michael Karin,Antonio Costanzo +13 more
TL;DR: In SCCs that are unable to shuttle IKKα to the nucleus, defective TGF-β-induced growth arrest was rescued by introduction of a constitutively nuclear IKKβ variant, and results suggest that the tumor-suppressive activity of IKK α in stratified epithelia may be exerted in part via the T GF-β signaling pathway.
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A Dual Role for Ikkα in Tooth Development
Atsushi Ohazama,Yinling Hu,Yinling Hu,Ruth Schmidt-Ullrich,Yixue Cao,Claus Scheidereit,Michael Karin,Paul T. Sharpe +7 more
TL;DR: IKK alpha is a component of the I kappa B kinase (IKK) complex that plays a key role in the activation of NF-kappa B as discussed by the authors.