M
Michael Karin
Researcher at University of California, San Diego
Publications - 753
Citations - 246120
Michael Karin is an academic researcher from University of California, San Diego. The author has contributed to research in topics: IκB kinase & Signal transduction. The author has an hindex of 236, co-authored 704 publications receiving 226485 citations. Previous affiliations of Michael Karin include Sanford-Burnham Institute for Medical Research & University of California, Los Angeles.
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Journal ArticleDOI
Inflammation Improves Glucose Homeostasis through IKKβ-XBP1s Interaction
Junli Liu,Dorina Ibi,Koji Taniguchi,Jaemin Lee,Hilde Herrema,Bedia Akosman,Patrick Mucka,Mario Andrés Salazar Hernández,Muhemmet Fatih Uyar,Sang Won Park,Michael Karin,Umut Ozcan +11 more
TL;DR: It is shown here, contrary to expectation, that IKK β-mediated inflammation is a positive regulator of hepatic glucose homeostasis and a beneficial role of IKKβ-mediated hepatic inflammation in glucoseHomeostasis is revealed.
Journal ArticleDOI
The yeast and mammalian Ras pathways control transcription of heat shock genes independently of heat shock transcription factor
TL;DR: In mammals, as in Saccharomyces cerevisiae, the Ras pathway controls the transcription of heat shock genes via a mechanism not involving the heat shock transcription factor.
Journal Article
Jun and v-jun contain multiple regions that participate in transcriptional activation in an interdependent manner.
TL;DR: It is shown that both the cellular Jun and its viral counterpart, v-Jun, are efficient transcriptional activators even in the absence of Fos, and once given the ability to bind DNA on its own, Fos is also an independent trans-activator.
Journal ArticleDOI
Neutrophil-Derived IL-1β Impairs the Efficacy of NF-κB Inhibitors against Lung Cancer
Allyson G. McLoed,Taylor P. Sherrill,Dong-Sheng Cheng,Wei Han,Jamie A. Saxon,Linda A. Gleaves,Pingsheng Wu,Vasiliy V. Polosukhin,Michael Karin,Fiona E. Yull,Georgios T. Stathopoulos,Georgios T. Stathopoulos,Georgios T. Stathopoulos,Vassilis Georgoulias,Rinat Zaynagetdinov,Timothy S. Blackwell +15 more
TL;DR: An important role for neutrophils and IL-1β in lung carcinogenesis and resistance to NF-κB inhibitors are elucidated and bortezomib treatment reduced tumor formation and growth in vivo.
Journal ArticleDOI
B-cell activating factor and v-Myc myelocytomatosis viral oncogene homolog (c-Myc) influence progression of chronic lymphocytic leukemia.
Weizhou Zhang,Arnon P. Kater,George F. Widhopf,Han-Yu Chuang,Thomas Enzler,Danelle F. James,Maxim Poustovoitov,Ping Hui Tseng,Siegfried Janz,Carl K. Hoh,Harvey R. Herschman,Michael Karin,Thomas J. Kipps +12 more
TL;DR: This study reveals an important relationship between BAFF and c-MYC in CLL which may affect disease development and progression, and suggests that inhibitors of the canonical NF-κB pathway may be effective in treatment of patients with this disease.