M
Michael Karin
Researcher at University of California, San Diego
Publications - 753
Citations - 246120
Michael Karin is an academic researcher from University of California, San Diego. The author has contributed to research in topics: IκB kinase & Signal transduction. The author has an hindex of 236, co-authored 704 publications receiving 226485 citations. Previous affiliations of Michael Karin include Sanford-Burnham Institute for Medical Research & University of California, Los Angeles.
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Crystal structure of inhibitor of kappaB kinase beta.
Guozhou Xu,Yu Chih Lo,Qiubai Li,Gennaro Napolitano,Xuefeng Wu,Xuliang Jiang,Michel Dreano,Michael Karin,Hao Wu +8 more
TL;DR: The structure reveals a trimodular architecture comprising the kinase domain, a ubiquitin-like domain (ULD) and an elongated, {alpha}-helical scaffold/dimerization domain (SDD), and the predicted leucine zipper and helix-loop-helix motifs do not form these structures but are part of the SDD.
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AP-1 Repressor Protein JDP-2: Inhibition of UV-Mediated Apoptosis through p53 Down-Regulation
TL;DR: JDP-2, but not JDP-1, is transiently induced upon UV challenge and that elevated levels of J DP-2 increase cell survival following UV exposure, via a conserved atypical AP-1 site in the p53promoter.
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Progesterone induction of metallothionein-IIA gene expression.
TL;DR: In human cell lines containing functional progesterone receptors, the endogenous metallothionein-IIA (hMTIIA) gene is inducible by the synthetic progestins R5020 and medroxy-progesterone acetate and reflects a direct interaction with the metallothsionein gene.
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Hypoestoxide, a Novel Anti-inflammatory Natural Diterpene, Inhibits the Activity of IκB Kinase
Emmanuel A. Ojo-Amaize,Pankaj Kapahi,Vellalore N. Kakkanaiah,Takayuki Takahashi,Tali Shalom-Barak,Howard B. Cottam,Akinbo A. Adesomoju,Emeka J. Nchekwube,Olusola A. Oyemade,Michael Karin,Joseph I. Okogun +10 more
TL;DR: It is demonstrated that hypoestoxide (HE) abrogates the production of pro-inflammatory cytokines (IL-1beta, IL-6, and TNF-alpha) in lipopolysaccharide (LPS)-activated normal human peripheral blood mononuclear cells and inhibition of nitric oxide by IL-1 beta- or IL-17-stimulated normal human chondrocytes.
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The pituitary-specific regulatory gene GHF1 contains a minimal cell type-specific promoter centered around its TATA box.
TL;DR: The minimal sequences required for differential transcription of GHF1 in GH-expressing and -nonexpressing cell lines and somatic cell hybrids were localized to a 15-bp region surrounding and including its TATA box, which acts as a cell type-specific promoter element.