Jewish Hospital

About: Jewish Hospital is a healthcare organization based out in Cincinnati, Ohio, United States. It is known for research contribution in the topics: Antigen & Population. The organization has 3881 authors who have published 3414 publications receiving 123044 citations.

Differential NK Cell and Macrophage Killing of Hamster Cells Infected with Nononcogenic or Oncogenic Adenovirus

Abstract: Hamster cells infected with highly oncogenic human adenovirus type 12 (Ad12) were resistant to lysis by natural killer cells and macrophages, compared to cells infected with nononcogenic adenovirus type 2 (Ad2). The data suggest that early adenovirus gene expression in hamster cells results in preferential survival of Ad12, compared to Ad2, infected cells in vivo, thus providing an explanation for the differences in the oncogenicities of these two transforming viruses.

Depletion and replenishment of the inorganic polyphosphate pool in neurospora crassa

Abstract: Harold, F. M. (National Jewish Hospital, Denver, Colo.). Depletion and replenishment of the inorganic polyphosphate pool in Neurospora crassa. J. Bacteriol. 83:1047–1057. 1962.—Turnover of the inorganic polyphosphate pool of Neurospora crassa was demonstrated in both growing and nongrowing mycelium. In nitrogen-deficient cultures, polyphosphate synthesis and degradation were in balance and no net changes occurred. When mycelium was suspended in a growth medium deficient in phosphate, polyphosphate was degraded to acid-soluble compounds, including adenosine triphosphate (ATP) and orthophosphate; net synthesis of nucleic acids and phospholipids occurred at the expense of polyphosphate. Various attempts were made to demonstrate direct formation of ATP from polyphosphate when oxidative and fermentative ATP generation were blocked. No evidence for this reaction could be obtained, suggesting that the primary product of polyphosphate degradation is not ATP but probably orthophosphate. Addition of phosphate to phosphate-starved mycelium induced rapid replenishment of the polyphosphate pool; polyphosphate accumulation ceased abruptly when the original level had been restored. The finding that ATP accumulation within the mycelium preceded polyphosphate synthesis, together with the rapid turnover of this compound, supports the view that ATP is the metabolic precursor of polyphosphate. The results suggest a cyclic pattern of polyphosphate metabolism. In N. crassa at least, polyphosphate does not appear to function as a reservoir of “high-energy” phosphate, but the polyphosphate cycle may be involved in the dissipation of excess ATP.

Oral cavity complications of bone marrow transplantation.

Abstract: Bone marrow transplantation, once regarded as experimental, has evolved into a standard treatment for a variety of malignancies. Considerable advances have been made in histocompatibility typing, pretransplantation chemotherapy, and posttransplantation immunosuppressive therapy as well as prophylaxis and treatment of infections. Oral complications develop in almost all patients, and their early recognition may result in the institution of prompt treatment and prolonged survival. Mucositis, often severe and extremely painful, develops in more than three quarters of bone marrow transplant recipients, and its prevention, unfortunately, remains unsatisfactory. Herpes simplex virus and Candida albicans account for most oral infections, although their incidence has been dramatically reduced by the institution of prophylactic agents. Graft versus host disease continues to be a significant complication of marrow transplantation, and the detection of commonly occurring oral changes may support its diagnosis.