Institution
Jewish Hospital
Healthcare•Cincinnati, Ohio, United States•
About: Jewish Hospital is a healthcare organization based out in Cincinnati, Ohio, United States. It is known for research contribution in the topics: Antigen & Population. The organization has 3881 authors who have published 3414 publications receiving 123044 citations.
Topics: Antigen, Population, Pregnancy, Antibody, Transplantation
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TL;DR: It is reported that IL‐4 inhibits the formation of osteoclasts from murine bone marrow cells cocultured with stromal cells, and the rat antimurineIL‐4 monoclonal antibody 11B11 antagonizes the IL‐ 4‐inhibitory effect on osteoclast formation.
Abstract: Interleukin 4 (IL-4) is a product of activated T cells and mast cells with effects on immunologic and hematopoietic processes We now report that IL-4 inhibits the formation of osteoclasts from murine bone marrow cells cocultured with stromal cells Numerous (3,000-4,000 cells/2 cm2) tartrate-resistant acid-phosphatase-positive multinucleated cells with the capacity to generate cAMP in response to salmon calcitonin (ED50 = 10(-10) M) developed within 10-12 days of culture IL-4 (ID50 = 10 U/ml) inhibited osteoclast generation in doses similar to those that induce proliferation of IL-4-responsive T cells Additionally, the rat antimurine IL-4 monoclonal antibody 11B11 antagonizes the IL-4-inhibitory effect on osteoclast formation These results suggest that IL-4 impedes agonist-induced in vitro bone resorption by inhibiting osteoclastogenesis
89 citations
TL;DR: Postoperatively, the patient improved by approximately 80% on the modified version of a myoclonus score without any significant change in the dystonic symptoms, suggesting that neurostimulation of the VIM may be an effective treatment for myOClonus in pharmacologically intractable IMDS.
Abstract: We report on the effects of bilateral neurostimulation of the ventral intermediate thalamic nucleus (VIM) in a patient with medically intractable and progressing inherited myoclonus dystonia syndrome (IMDS). Postoperatively, the patient improved by approximately 80% on the modified version of a myoclonus score without any significant change in the dystonic symptoms. This suggests that neurostimulation of the VIM may be an effective treatment for myoclonus in pharmacologically intractable IMDS.
89 citations
TL;DR: The lack of molecular species heterogeneity of PAF produced in response to stimuli implies a higher degree of control of biosynthesis than previously suspected.
89 citations
TL;DR: The results suggest that changes in Mg2+ metabolism play important roles in stroke syndromes and in the etiology of cerebrovasospasm associated with cerebral hemorrhage.
89 citations
TL;DR: Although the authors cannot completely rule out O3 diffusion to the RCM, product(s) derived from O3 + AH2/GSH reactions (possibly O3*- or 1O2) likely initiated RCM oxidation and may suggest that in vivo, such secondary species account for O3 permeation through the ELF leading to cellular perturbations.
88 citations
Authors
Showing all 3894 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| John C. Morris | 183 | 1441 | 168413 |
| David L. Kaplan | 177 | 1944 | 146082 |
| Robert H. Purcell | 139 | 666 | 70366 |
| Nancy J. Cox | 135 | 778 | 109195 |
| Jennifer S. Haas | 128 | 840 | 71315 |
| David A. Cheresh | 125 | 337 | 62252 |
| John W. Kappler | 122 | 464 | 57541 |
| Philippa Marrack | 120 | 416 | 54345 |
| Arthur Weiss | 117 | 380 | 45703 |
| Thomas J. Kipps | 114 | 748 | 63240 |
| Michael Pollak | 114 | 663 | 57793 |
| Peter M. Henson | 112 | 369 | 54246 |
| Roberto Bolli | 111 | 528 | 44010 |
| William D. Foulkes | 108 | 682 | 45013 |
| David A. Lynch | 108 | 714 | 59678 |