Jewish Hospital

About: Jewish Hospital is a healthcare organization based out in Cincinnati, Ohio, United States. It is known for research contribution in the topics: Antigen & Population. The organization has 3881 authors who have published 3414 publications receiving 123044 citations.

Histone deacetylation contributes to low extracellular superoxide dismutase expression in human idiopathic pulmonary arterial hypertension.

Abstract: Epigenetic mechanisms, including DNA methylation and histone acetylation, regulate gene expression in idiopathic pulmonary arterial hypertension (IPAH). These mechanisms can modulate expression of ...

Appearance-based diagnostic system for early assessment of malignant lung nodules

Abstract: A novel 2D approach for early assessment of malignant lung nodules based on analyzing the spatial distribution of Hounsfield values for the detected lung nodules is proposed. Spatial distribution of Hounsfield values comprising the malignant nodule appearance is accurately modeled with a new 2D rotationally invariant second-order Markov-Gibbs Random Field (MGRF). Preliminary experiments on 109 lung nodules (51 malignant and 58 benign) show that the proposed method is a promising supplement to current technologies (biopsy-based diagnostic systems) for the early diagnosis of lung cancer.

Rigid ureteroscopy for diagnosis and treatment of ureteral calculi during pregnancy.

Abstract: OBJECTIVE To evaluate ureteroscopy as a treatment option for women presenting ureteral calculi during pregnancy. MATERIALS AND METHODS Eighteen pregnant patients presenting renal colic and indication of surgical treatment for ureteral calculi were analyzed. Patients were 20 to 34 years old (medium = 28), and the gestation period ranged from 12 to 34 weeks (medium = 18). Lumbar pain was present in 14 patients, and 4 had diffuse abdominal pain. Four patients were febrile in the occasion of the examination. Thirteen patients presented microscopic hematuria, 8 leucocituria, and 4 positive urine culture. The stone was detected by ultrasonography (US) in 12 patients. Magnetic resonance imaging (MRI) was performed in 2 cases, and did not demonstrate calculi. The stone location was: 1 in the superior ureter (pregnancy of 15 weeks), 4 in the medium ureter (pregnancy of 12, 15, 18 and 20 weeks), 12 in the inferior ureter, and 1 was not determined. The surgical indication was difficult pain control, fever, and presence of uterine contractions. RESULTS Double-J insertion, as single treatment, was possible in 4 patients and it was kept in place for up to 2 weeks after delivery. Among the patients submitted to ureteroscopy, the calculi retrieval was always possible, except in 1 case where the calculus was not located by US, MRI or ureteroscopy. In 2 patients, the ultrasonic lithotriptor was used and in 11 the stone was removed intact with a basket. There were no complications due to the procedure and all pregnancies were carried to full term. CONCLUSION Rigid ureteroscopy for extraction of ureteral calculi during pregnancy is efficient and safe.

Detection and recognition of lung abnormalities using deformable templates

Abstract: Automatic detection and recognition of lung cancer during mass screening of spiral computer tomographic (CT) chest scans is one of the most important problems of today's medical image analysis. We propose an algorithm for isolating lung abnormalities (nodules) from arteries, veins, bronchi, and bronchioles after all these objects have been already separated from the surrounding anatomical structures. The separation is presented elsewhere, and this paper focuses on nodule detection using deformable 3D and 2D templates describing typical geometry and gray level distribution within the nodules of the same type. The detection combines normalized cross-correlation template matching by genetic optimization and Bayesian post-classification. Experiments with 200 spiral low dose CT (LDCT) scans confirm the accuracy of our approach.