Jewish Hospital

About: Jewish Hospital is a healthcare organization based out in Cincinnati, Ohio, United States. It is known for research contribution in the topics: Antigen & Population. The organization has 3881 authors who have published 3414 publications receiving 123044 citations.

Appearance analysis for diagnosing malignant lung nodules

Abstract: An alternative method of diagnosing malignant lung nodules by their visual appearance rather than conventional growth rate is proposed. Spatial distribution of image intensities (or Hounsfield values) comprising the malignant nodule appearance is accurately modeled with a rotation invariant second-order Markov-Gibbs random field. Its neighborhood system and potentials are analytically learned from a training set of nodule images with normalized intensity ranges. Preliminary experiments on 109 lung nodules (51 malignant and 58 benign ones) resulted in the 96.3% correct classification (for the 95% confidence interval), showing the proposed method is a promising supplement to current technologies for early diagnostics of lung cancer.

Plasma steroid concentrations during alternate-day treatment with prednisone

Abstract: Plasma steroid concentrations were measured in asthmatic children 24 and 48 hours after administration of alternate-day treatment with prednisone, and the results were compared with those of control patients who did not receive corticosteroid treatment as well as those of patients who were treated with prednisone each day. It was found that 24 hours after administration of prednisone in any dose, plasma steroid concentrations were significantly lower than those of the control group. The degree of suppression in plasma steroid concentration was less marked in patients who received treatment on alternate days than in those who received the same doses of prednisone each day. Within 48 hours after administration of alternate-day treatment, plasma steroid concentrations approached the values observed in the control group and were independent of the magnitude of the prednisone dose. Although alternateday steroid treatment was associated with transient and incomplete suppression of pituitary-adrenal function, patients whose therapy was changed from a daily to an alternate-day regimen sometimes exhibited prolonged suppression of adrenal cortical function.