Jewish Hospital

About: Jewish Hospital is a healthcare organization based out in Cincinnati, Ohio, United States. It is known for research contribution in the topics: Antigen & Population. The organization has 3881 authors who have published 3414 publications receiving 123044 citations.

Subjective symptoms of acute asthma within a heterogeneous sample of asthmatics

Abstract: A heterogeneous group of 175 severe asthma inpatients with perennial symptoms were asked to rate the frequency with which 77 symptoms occurred during their asthma attacks. The reported frequency of occurrence for individual symptoms and symptom categories of panic-fear, irritability, fatigue, hyperventilation-hypocapnia, and airway obstruction are presented. As expected, airway obstruction symptoms were the most frequently reported during acute asthmatic episodes. In decreasing order, the airway obstruction symptoms were followed by fatigue, panic-fear, irritability, and hyperventilation-hypocapnia. A separation of the patient sample into subgroups revealed no differences in reported occurrence of the symptom categories associated with age, age at onset, or length of illness. Females reported experiencing panic-fear and fatigue symptoms more frequently than males. Patients who subsequently had higher steroid regimens prescribed at discharge reported more frequent panic-fear symptoms. Those patients with an infectious component in their asthma reported symptoms of panic-fear, fatigue, and airway obstruction somewhat more frequently than those classified as having no infectious component in their asthma. The results suggest that subjective symptomatology may provide important clues concerning the nature of emotional factors in asthma and response to treatment.

Serial 1H-MRS in relapsing-remitting multiple sclerosis: effects of interferon-β therapy on absolute metabolite concentrations

Abstract: To assess the applicability of magnetic resonance spectroscopy (MRS) for long-term follow-up of neurological diseases a longitudinal 1H-MRS study at 3 T was carried out on ten patients having relapsing-remitting multiple sclerosis (MS) who, after baseline examination, received interferon-β (IFN) lb. At 8–20 examinations within up to 34 months absolute concentrations ofN-acetylaspartate (NAA), total creatine (tG), and choline-containing compounds (tCho) were determined in a large non-enhancing lesion and contralateral normal appearing white matter (NAWM). MR spectra were analyzed using a novel time domain-frequency domain method including non-parametric background characterization. For comparison at baseline, ten healthy controls were examined. The concentrations of tCho and tCr were found to be higher in MS brain than in control brain. Besides a non-significantly lower NAA concentration in lesions there were no concentration differences between lesions and NAWM. Over the follow-up period the measured metabolite concentrations exhibited a high variability. Most concentrations remained within this scatter, and statistical tests revealed significant fluctuations in the levels of metabolites in one case only. This stability of the metabolite concentrations over time might result from IFN therapy as for the spontaneous course of relapsing-remitting MS decreasing metabolite (NAA/tCr) ratios have been reported. The results further suggest that future treatment trials intending to use metabolite concentrations as a secondary outcome indicator use even longer observation periods and, besides group analysis of large cohorts, investigate the time behavior of selected single cases. The biochemical abnormalities found in NAWM emphasize the importance of analyzing both lesion and NAWM.

Acute nonlymphoblastic leukemia in childhood. High incidence of clonal abnormalities and nonrandom changes

Abstract: Cytogenetic studies have been done on a group of childhood patients over a period of 3 1/2 years in which time Giemsa trypsin banding was applied to all specimens. Fifteen of the 107 patients (14%) were diagnosed as having acute nonlymphoblastic leukemia (ANLL). Twelve of the 15 had chromosomal abnormalities. The most common was an involvement of the No. 7 chromosome which occurred in five patients. Three patients had trisomy 19. No correlation could be found between the disease subgroup and the karyotypic aberration in patients with anomalies involving a common chromosome.