National Cheng Kung University

About: National Cheng Kung University is a education organization based out in Tainan City, Taiwan. It is known for research contribution in the topics: Population & Thin film. The organization has 49723 authors who have published 69799 publications receiving 1437420 citations. The organization is also known as: NCKU.

Sustainability of direct biodiesel synthesis from microalgae biomass: a critical review.

Abstract: Microalgae has been identified as a potential feedstock for biodiesel production since its cultivation requires less cropland compared to conventional oil crops and the high growth rate of microalgae. Research on microalgae oils often are focused on microalgae oil extraction and biomass harvesting techniques. However, energy intensive and costly lipid extraction methods are the major obstacles hampering microalgae biodiesel commercialisation. Direct biodiesel synthesis avoids such problems as it combines lipid extraction techniques and transesterification into a single step. In this review, the potential of direct biodiesel synthesis from microalgae biomass was comprehensively analysed. The various species of microalgae commonly used as biodiesel feedstock was critically assessed, particularly on high lipid content species. The production of microalgae biodiesel via direct conversion from biomass was systematically discussed, covering major enhancements such as heterogeneous catalysts, the use of ultrasonic and microwave- techniques and supercritical alcohols that focus on the overall improvement of biodiesel production. In addition, this review illustrates the cultivation conditions for biomass growth and lipid productivity improvement, the available harvesting and lipid extraction technologies, as well as the key challenges and future prospect of microalgae biodiesel production. This review serves as a basis for future research on direct biodiesel synthesis from modified microalgae biomass to improve profitability of microalgae biodiesel.

Histopathological differential diagnosis of keloid and hypertrophic scar

Abstract: Distinguishing hypertrophic scar (HS) from keloid histopathologically is sometimes difficult because thickened hyalinized collagen (keloidal collagen), the hallmark of keloid, is not always detectable and alpha-smooth muscle actin (alpha-SMA), a differentiating marker of HS, is variably expressed in both forms of scar. The aim of this study was to investigate additional distinguishing features to facilitate differentiation between keloid and HS. We compared various histologic features and the expression of alpha-SMA in 40 specimens of keloid and 10 specimens of HS. The features more commonly seen in keloids were: (a) no flattening of the overlying epidermis, (b) no scarring of the papillary dermis, (c) presence of keloidal collagen, (d) absence of prominent vertically oriented blood vessels, (e) presence of prominent disarray of fibrous fascicles/nodules, (f) presence of a tongue-like advancing edge underneath normal-appearing epidermis and papillary dermis, (g) horizontal cellular fibrous band in the upper reticular dermis, and (h) prominent fascia-like fibrous band. The last three features were found in keloid specimens only, including the ones lacking detectable keloidal collagen. Our study confirmed the diagnostic value of keloidal collagen, but it was only found in 55% of keloid specimens. Alpha-SMA expression was found in both HS (70%) and keloid (45%), thus it would not be a differentiating marker. In scars with no detectable keloidal collagen, the presence of the following feature(s) favors the diagnosis of keloid: non-flattened epidermis, non-fibrotic papillary dermis, a tongue-like advancing edge, horizontal cellular fibrous band in the upper reticular dermis, and prominent fascia-like band.