Rensselaer Polytechnic Institute

About: Rensselaer Polytechnic Institute is a education organization based out in Troy, New York, United States. It is known for research contribution in the topics: Terahertz radiation & Finite element method. The organization has 19024 authors who have published 39922 publications receiving 1414699 citations. The organization is also known as: RPI & Rensselaer Institute.

Radio-wave heating of iron oxide nanoparticles can regulate plasma glucose in mice.

Abstract: Medical applications of nanotechnology typically focus on drug delivery and biosensors. Here, we combine nanotechnology and bioengineering to demonstrate that nanoparticles can be used to remotely regulate protein production in vivo. We decorated a modified temperature-sensitive channel, TRPV1, with antibody-coated iron oxide nanoparticles that are heated in a low-frequency magnetic field. When local temperature rises, TRPV1 gates calcium to stimulate synthesis and release of bioengineered insulin driven by a Ca 2+ -sensitive promoter. Studying tumor xenografts expressing the bioengineered insulin gene, we show that exposure to radio waves stimulates insulin release from the tumors and lowers blood glucose in mice. We further show that cells can be engineered to synthesize genetically encoded ferritin nanoparticles and inducibly release insulin. These approaches provide a platform for using nanotechnology to activate cells.

This Just In: Fake News Packs a Lot in Title, Uses Simpler, Repetitive Content in Text Body, More Similar to Satire than Real News

Abstract: The problem of fake news has gained a lot of attention as it is claimed to have had a significant impact on 2016 US Presidential Elections. Fake news is not a new problem and its spread in social networks is well-studied. Often an underlying assumption in fake news discussion is that it is written to look like real news, fooling the reader who does not check for reliability of the sources or the arguments in its content. Through a unique study of three data sets and features that capture the style and the language of articles, we show that this assumption is not true. Fake news in most cases is more similar to satire than to real news, leading us to conclude that persuasion in fake news is achieved through heuristics rather than the strength of arguments. We show overall title structure and the use of proper nouns in titles are very significant in differentiating fake from real. This leads us to conclude that fake news is targeted for audiences who are not likely to read beyond titles and is aimed at creating mental associations between entities and claims.

Macromolecular modeling and design in Rosetta: recent methods and frameworks

Abstract: The Rosetta software for macromolecular modeling, docking and design is extensively used in laboratories worldwide. During two decades of development by a community of laboratories at more than 60 institutions, Rosetta has been continuously refactored and extended. Its advantages are its performance and interoperability between broad modeling capabilities. Here we review tools developed in the last 5 years, including over 80 methods. We discuss improvements to the score function, user interfaces and usability. Rosetta is available at http://www.rosettacommons.org.

Evaluation of anti-islanding schemes based on nondetection zone concept

Abstract: This paper proposes a nondetection zone (NDZ) as a performance index to evaluate different anti-islanding schemes. The NDZ for three basic passive anti-islanding schemes: under/over voltage, under/over frequency, and phase jump are derived analytically and validated by simulation. Based on the NDZ, not only can the dominant factors that influence anti-islanding protection be identified, it may also support definition of optimal combined schemes that lead to a reduced NDZ. The methodology presented in the paper can be extended to the evaluation of other anti-islanding schemes.

Environmentally Induced Positive Affect: Its Impact on Self-Efficacy, Task Performance, Negotiation, and Conflict1

Abstract: Male and female subjects performed several tasks either in the presence or absence of an environmental source of positive affect (pleasant artificial scents produced by two commercially manufactured air-fresheners). Consistent with the findings of previous research on the impact of positive affect, results indicated that several aspects of subjects' behavior were influenced by this variable. Participants exposed to pleasant scents set higher goals on a clerical coding task and were more likely to adopt an efficient strategy for performing this task than subjects not exposed to such conditions. In addition, males (but not females) reported higher self-efficacy in the presence of pleasant artificial scents than in their absence. Participants exposed to pleasant scents also set higher monetary goals and made more concessions during face-to-face negotiations with an accomplice. Finally, subjects exposed to pleasant scents reported weaker preferences for handling future conflicts with the accomplice through avoidance and competition. Analyses of covariance suggested that these differences stemmed largely from contrasting levels of positive affect among subjects in the neutral and pleasant scent conditions. Together, these results suggest that pleasant artificial scents may provide a potentially useful means for enhancing the environmental quality of work settings, and hence the performance and attitudes of persons in them.