Institution
San Diego State University
Education•San Diego, California, United States•
About: San Diego State University is a education organization based out in San Diego, California, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 12418 authors who have published 27950 publications receiving 1192375 citations. The organization is also known as: SDSU & San Diego State College.
Papers published on a yearly basis
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TL;DR: It is suggested that CRC-associated physiological and metabolic changes recruit tumor-foraging commensal-like bacteria that have an apparent competitive advantage in the tumor microenvironment and thereby seem to replace pathogenic bacteria that may be implicated in CRC etiology.
Abstract: Multiple factors drive the progression from healthy mucosa towards sporadic colorectal carcinomas and accumulating evidence associates intestinal bacteria with disease initiation and progression. Therefore, the aim of this study was to provide a first high-resolution map of colonic dysbiosis that is associated with human colorectal cancer (CRC). To this purpose, the microbiomes colonizing colon tumor tissue and adjacent non-malignant mucosa were compared by deep rRNA sequencing. The results revealed striking differences in microbial colonization patterns between these two sites. Although inter-individual colonization in CRC patients was variable, tumors consistently formed a niche for Coriobacteria and other proposed probiotic bacterial species, while potentially pathogenic Enterobacteria were underrepresented in tumor tissue. As the intestinal microbiota is generally stable during adult life, these findings suggest that CRC-associated physiological and metabolic changes recruit tumor-foraging commensal-like bacteria. These microbes thus have an apparent competitive advantage in the tumor microenvironment and thereby seem to replace pathogenic bacteria that may be implicated in CRC etiology. This first glimpse of the CRC microbiome provides an important step towards full understanding of the dynamic interplay between intestinal microbial ecology and sporadic CRC, which may provide important leads towards novel microbiome-related diagnostic tools and therapeutic interventions.
505 citations
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University of Arizona1, University of South Dakota2, University of New Mexico3, Stellenbosch University4, Stanford University5, University at Buffalo6, University of Washington7, University of Mississippi8, Wake Forest University9, Emory University10, University of California, San Diego11, University of Cape Town12, University of Michigan13, San Diego State University14, Boston University15, National Institutes of Health16, University of North Carolina at Chapel Hill17
TL;DR: In this paper, the authors present updated diagnostic guidelines based on a thorough review of the literature and the authors' combined expertise based on the evaluation of >10,000 children for potential fetal alcohol spectrum disorders in clinical settings and in epidemiologic studies in conjunction with National Institute on Alcohol Abuse and Alcoholism-funded studies, the Collaborative Initiative on Fetal Alcohol Spectrum Disorders, and the Collaboration on FASD Prevalence.
Abstract: The adverse effects of prenatal alcohol exposure constitute a continuum of disabilities (fetal alcohol spectrum disorders [FASD]). In 1996, the Institute of Medicine established diagnostic categories delineating the spectrum but not specifying clinical criteria by which diagnoses could be assigned. In 2005, the authors published practical guidelines operationalizing the Institute of Medicine categories, allowing for standardization of FASD diagnoses in clinical settings. The purpose of the current report is to present updated diagnostic guidelines based on a thorough review of the literature and the authors’ combined expertise based on the evaluation of >10 000 children for potential FASD in clinical settings and in epidemiologic studies in conjunction with National Institute on Alcohol Abuse and Alcoholism–funded studies, the Collaborative Initiative on Fetal Alcohol Spectrum Disorders, and the Collaboration on FASD Prevalence. The guidelines were formulated through conference calls and meetings held at National Institute on Alcohol Abuse and Alcoholism offices in Rockville, MD. Specific areas addressed include the following: precise definition of documented prenatal alcohol exposure; neurobehavioral criteria for diagnosis of fetal alcohol syndrome, partial fetal alcohol syndrome, and alcohol-related neurodevelopmental disorder; revised diagnostic criteria for alcohol-related birth defects; an updated comprehensive research dysmorphology scoring system; and a new lip/philtrum guide for the white population, incorporating a 45-degree view. The guidelines reflect consensus among a large and experienced cadre of FASD investigators in the fields of dysmorphology, epidemiology, neurology, psychology, developmental/behavioral pediatrics, and educational diagnostics. Their improved clarity and specificity will guide clinicians in accurate diagnosis of infants and children prenatally exposed to alcohol.
503 citations
01 Feb 2002
TL;DR: In this paper, the authors present protocols for measuring bio-optical and radiometric data for the SIMBIOS Project, which is organized into four parts: Introductory Background, Instrument Characteristics, Field Measurements and Data Analysis, Data Reporting and Archival.
Abstract: This document stipulates protocols for measuring bio-optical and radiometric data for the SIMBIOS Project. It supersedes the earlier version, and is organized into four parts: Introductory Background, Instrument Characteristics, Field Measurements and Data Analysis, Data Reporting and Archival. Changes in this revision include the addition of three new chapters: (1) Fundamental Definitions, Relationships and Conventions; (2) MOBY, A Radiometric Buoy for Performance Monitoring and Vicarious Calibration of Satellite Ocean Color Sensors: Measurement and Data Analysis Protocols; and (3) Normalized Water-Leaving Radiance and Remote Sensing Reflectance: Bidirectional Reflectance and Other Factors. Although the present document represents another significant, incremental improvement in the ocean optics protocols, there are several protocols that have either been overtaken by recent technological progress, or have been otherwise identified as inadequate. Revision 4 is scheduled for completion sometime in 2003. This technical report is not meant as a substitute for scientific literature. Instead, it will provide a ready and responsive vehicle for the multitude of technical reports issued by an operational Project. The contributions are published as submitted, after only minor editing to correct obvious grammatical or clerical errors.
502 citations
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TL;DR: A new and improved somatotype method with universal application to both sexes, for all ages and which is reproducible, is justified, validated and described and evidence is presented for extension of previous component rating scales.
Abstract: A new and improved somatotype method with universal application to both sexes, for all ages and which is reproducible, is justified, validated and described. Evidence is presented for extension of previous component rating scales. Data on 844 male and female subjects from selected samples were used to develop and validate anthropometric scales for estimating the Heath component ratings. The definitions and rating procedures for the new somatotype method are presented, with descriptions of the anthropometric somatotype and the combined photoscopic and anthropometric somatotype.
502 citations
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University of California, San Diego1, Kyushu University2, Keio University3, National Cheng Kung University4, Fox Chase Cancer Center5, Lamar University6, Fudan University7, United States Department of Veterans Affairs8, Medical University of South Carolina9, San Diego State University10, French Institute of Health and Medical Research11, University of Paris12
TL;DR: It is shown in mice and human cells that gp130, a co-receptor for IL-6 cytokines, triggers activation of YAP and Notch, transcriptional regulators that control tissue growth and regeneration, independently of the gp130 effector STAT3.
Abstract: Inflammation promotes regeneration of injured tissues through poorly understood mechanisms, some of which involve interleukin (IL)-6 family members, the expression of which is elevated in many diseases including inflammatory bowel diseases and colorectal cancer. Here we show in mice and human cells that gp130, a co-receptor for IL-6 cytokines, triggers activation of YAP and Notch, transcriptional regulators that control tissue growth and regeneration, independently of the gp130 effector STAT3. Through YAP and Notch, intestinal gp130 signalling stimulates epithelial cell proliferation, causes aberrant differentiation and confers resistance to mucosal erosion. gp130 associates with the related tyrosine kinases Src and Yes, which are activated on receptor engagement to phosphorylate YAP and induce its stabilization and nuclear translocation. This signalling module is strongly activated upon mucosal injury to promote healing and maintain barrier function.
501 citations
Authors
Showing all 12533 results
Name | H-index | Papers | Citations |
---|---|---|---|
David R. Williams | 178 | 2034 | 138789 |
James F. Sallis | 169 | 825 | 144836 |
Steven Williams | 144 | 1375 | 86712 |
Larry R. Squire | 143 | 472 | 85306 |
Murray B. Stein | 128 | 745 | 89513 |
Robert Edwards | 121 | 775 | 74552 |
Roberto Kolter | 120 | 315 | 52942 |
Jack E. Dixon | 115 | 408 | 47201 |
Sonia Ancoli-Israel | 115 | 520 | 46045 |
John D. Lambris | 114 | 651 | 48203 |
Igor Grant | 113 | 791 | 55147 |
Kenneth H. Nealson | 108 | 483 | 51100 |
Mark Westoby | 108 | 316 | 59095 |
Eric Courchesne | 107 | 240 | 41200 |
Marc A. Schuckit | 106 | 643 | 43484 |