Southeast University

About: Southeast University is a education organization based out in Nanjing, China. It is known for research contribution in the topics: Computer science & MIMO. The organization has 66363 authors who have published 79434 publications receiving 1170576 citations. The organization is also known as: SEU.

LncRNA SATB2-AS1 inhibits tumor metastasis and affects the tumor immune cell microenvironment in colorectal cancer by regulating SATB2

Abstract: Emerging studies suggest that long non-coding RNAs (lncRNAs) play crucial roles in colorectal cancer (CRC). Here, we report a lncRNA, SATB2-AS1, which is specifically expressed in colorectal tissue and is significantly reduced in CRC. We systematically elucidated its functions and possible molecular mechanisms in CRC. LncRNA expression in CRC was analyzed by RNA-sequencing and RNA microarrays. The expression level of SATB2-AS1 in tissues was determined by quantitative reverse transcription polymerase chain reaction (qRT-PCR) and in situ hybridization (ISH). The functional role of SATB2-AS1 in CRC was investigated by a series of in vivo and in vitro assays. RNA pull-down, RNA immunoprecipitation (RIP), chromatin immunoprecipitation (ChIP), chromatin isolation by RNA purification (ChIRP), Bisulfite Sequencing PCR (BSP) and bioinformatics analysis were utilized to explore the potential mechanisms of SATB2-AS1. SATB2-AS1 is specifically expressed in colorectal tissues and downregulated in CRC. Survival analysis indicates that decreased SATB2-AS1 expression is associated with poor survival. Functional experiments and bioinformatics analysis revealed that SATB2-AS1 inhibits CRC cell metastasis and regulates TH1-type chemokines expression and immune cell density in CRC. Mechanistically, SATB2-AS1 directly binds to WDR5 and GADD45A, cis-activating SATB2 (Special AT-rich binding protein 2) transcription via mediating histone H3 lysine 4 tri-methylation (H3K4me3) deposition and DNA demethylation of the promoter region of SATB2. This study reveals the functions of SATB2-AS1 in CRC tumorigenesis and progression, suggesting new biomarkers and therapeutic targets in CRC.

Bright and Stable Purple/Blue Emitting CdS/ZnS Core/Shell Nanocrystals Grown by Thermal Cycling Using a Single-Source Precursor

Abstract: A new approach for synthesis of high quality core/shell nanocrystals, “thermal-cycling coupled single precursor” (TC-SP), was developed. It was applied for the synthesis of high efficiency, good color purity, nearly monodisperse, alloying-free, and stable CdS/ZnS core/shell nanocrystals with their emission peak tunable between 375 and 475 nm. A comparison study on TC-SP versus the classic successive ionic layer adsorption and reaction (SILAR), both in one pot, revealed that, although the reaction temperature was significantly reduced and the procedure was simplified for TC-SP, the overall quality of the CdS/ZnS core/shell nanocrystals yielded by TC-SP was found to be superior. A quantitative chemical etching method was developed for determining the radial distribution of elements in bandgap/composition engineered nanocrystals.

Micro/Nanoscale Thermometry for Cellular Thermal Sensing

Abstract: Temperature is a key parameter to regulate cell function, and biochemical reactions inside a cell in turn affect the intracellular temperature. It's vitally necessary to measure cellular temperature to provide sufficient information to fully understand life science, while the conventional methods are incompetent. Over the last decade, many ingenious thermometers have been developed with the help of nanotechnology, and real-time intracellular temperature measurement at the micro/nanoscale has been realized with high temporal-spatial resolution. With the help of these techniques, several mechanisms of thermogenesis inside cells have been investigated, even in subcellular organelles. Here, current developments in cellular thermometers are highlighted, and a picture of their applications in cell biology is presented. In particular, temperature measurement principle, thermometer design and latest achievements are also introduced. Finally, the existing opportunities and challenges in this ongoing field are discussed.

Photoluminescence properties of a ScBO3:Cr3+ phosphor and its applications for broadband near-infrared LEDs

Abstract: The rapid extension of solid state lighting technologies offers the possibility to develop broadband near-infrared (NIR) phosphor-converted LEDs (pc-LEDs) as novel NIR light sources. In this paper, a new NIR-emitting phosphor ScBO3:Cr3+ was synthesized by a high temperature solid state reaction method. Phase structure, spectroscopic properties, luminescent lifetime, quantum yield, emitter concentration influences and thermal quenching behavior of ScBO3:Cr3+, as well as its applications for NIR pc-LEDs, were systematically investigated. ScBO3:Cr3+ phosphors exhibit a broad absorption band ranging from 400 to 530 nm, which matches well with the characteristic emission of the blue LED chip. Moreover, Cr3+ ions occupy the Sc3+ sites with relatively low crystal field strength in the ScBO3 host, and therefore ScBO3:Cr3+ phosphors show intense broadband emission peaking at ∼800 nm upon excitation at 460 nm, originating from spin-allowed 4T2 → 4A2 transition of Cr3+ ions. The optimum Cr3+ concentration was determined to be ∼2 mol% with a quantum yield of ∼65%. A broadband NIR pc-LED prototype device was fabricated by the combination of ScBO3:Cr3+ phosphors and a blue LED chip, which showed a maximum NIR light output power of ∼26 mW and a corresponding energy conversion efficiency of ∼7%. The results indicate the great potential of ScBO3:Cr3+ phosphors for applications in broadband NIR pc-LEDs.