Institution
University of Alabama
Education•Tuscaloosa, Alabama, United States•
About: University of Alabama is a education organization based out in Tuscaloosa, Alabama, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 27323 authors who have published 48609 publications receiving 1565337 citations. The organization is also known as: Alabama & Bama.
Topics: Population, Poison control, Galaxy, Health care, Large Hadron Collider
Papers published on a yearly basis
Papers
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TL;DR: In the third issue of the then new journal Green Chemistry (2001, 3, 156-164), the physical properties of a few hydrophilic and hydrophobic ionic liquids (ILs) representing one of the first such studies was published.
287 citations
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TL;DR: The origin of AIDS is more ancient than the origin of HIV-1, and tracing the genetic changes that occurred as monkey viruses adapted to infect first chimpanzees and then humans may provide insights into the causes of the pathogenicity of these viruses.
Abstract: The major cause of acquired immune deficiency syndrome (AIDS) is human immunodeficiency virus type 1 (HIV-1). We have been using evolutionary comparisons to trace (i) the origin(s) of HIV-1 and (ii) the origin(s) of AIDS. The closest relatives of HIV-1 are simian immunodeficiency viruses (SIVs) infecting wild-living chimpanzees (Pan troglodytes troglodytes) and gorillas (Gorilla gorilla gorilla) in west central Africa. Phylogenetic analyses have revealed the origins of HIV-1: chimpanzees were the original hosts of this clade of viruses; four lineages of HIV-1 have arisen by independent cross-species transmissions to humans and one or two of those transmissions may have been via gorillas. However, SIVs are primarily monkey viruses: more than 40 species of African monkeys are infected with their own, species-specific, SIV and in at least some host species, the infection seems non-pathogenic. Chimpanzees acquired from monkeys two distinct forms of SIVs that recombined to produce a virus with a unique genome structure. We have found that SIV infection causes CD4(+) T-cell depletion and increases mortality in wild chimpanzees, and so the origin of AIDS is more ancient than the origin of HIV-1. Tracing the genetic changes that occurred as monkey viruses adapted to infect first chimpanzees and then humans may provide insights into the causes of the pathogenicity of these viruses.
286 citations
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Istituto Giannina Gaslini1, Karolinska Institutet2, Military Medical Academy3, Capital Medical University4, University of Hamburg5, University of Toronto6, Katholieke Universiteit Leuven7, Boston Children's Hospital8, Hacettepe University9, University of Barcelona10, Jaslok Hospital11, Istanbul University12, University of Calgary13, National and Kapodistrian University of Athens14, Autonomous University of Madrid15, Temple University16, University of Naples Federico II17, Saint Petersburg State Pediatric Medical University18, University of Oslo19, Shanghai Jiao Tong University20, Aichi Medical University21, University of Ljubljana22, University of Münster23, Cincinnati Children's Hospital Medical Center24, Izaak Walton Killam Health Centre25, University of Zagreb26, University of Genoa27, University of Alabama28
TL;DR: In this paper, the authors describe the clinical, laboratory, and histopathologic features, current treatment, and outcome of patients with macrophage activation syndrome (MAS) complicating systemic juvenile idiopathic arthritis (JIA).
Abstract: Objective
To describe the clinical, laboratory, and histopathologic features, current treatment, and outcome of patients with macrophage activation syndrome (MAS) complicating systemic juvenile idiopathic arthritis (JIA).
Methods
In this multinational, multicenter study, pediatric rheumatologists and hemato-oncologists entered patient data collected retrospectively into a web-based database.
Results
A total of 362 patients, 22% of whom had MAS at the onset of systemic JIA, were included in the study by 95 investigators from 33 countries. The most frequent clinical manifestations were fever (96%), hepatomegaly (70%), and splenomegaly (58%). Central nervous system dysfunction and hemorrhages were recorded in 35% and 20% of the patients, respectively. Platelet count and liver transaminase, ferritin, lactate dehydrogenase, triglyceride, and d-dimer levels were the sole laboratory biomarkers showing a percentage change of >50% between the pre-MAS visit and MAS onset. Evidence of macrophage hemophagocytosis was found in 60% of the patients who underwent bone marrow aspiration. MAS occurred most frequently in the setting of active underlying disease, in the absence of a specific trigger. Nearly all patients were given corticosteroids, and 61% received cyclosporine. Biologic medications and etoposide were given to 15% and 12% of the patients, respectively. Approximately one-third of the patients required admission to the intensive care unit (ICU), and the mortality rate was 8%.
Conclusion
This study provides information on the clinical spectrum and current management of systemic JIA–associated MAS through the analysis of a very large patient sample. MAS remains a serious condition, as a sizeable proportion of patients required admission to the ICU or died.
286 citations
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TL;DR: In this article, the authors examine several work climate variables and their impact on service quality and show that both climate variables contribute directly to job satisfaction and work effort, and indirectly impact on customers' perceptions of employee service quality.
Abstract: This paper examines several work climate variables and their impact on service quality. While there exists a variety of work climates relevant to contact employees during service encounters, this study investigates two components for successful implementation of internal marketing, service climate and supportive management. Both climate variables are proposed to affect the attitudes and behaviors of employees, and consequently affect customers’ perceptions of employees’ service performance. This study, which combines perceptions from customers and their contact employees, shows that both climate variables contribute directly to job satisfaction and work effort, and indirectly impact on customers’ perceptions of employee service quality. Also, the empirical results indicate that in addition to job satisfaction, employees’ work effort also plays a strong, central role in determining customers’ perceptions of employee service quality.
285 citations
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Vardan Khachatryan1, Robin Erbacher2, C. A. Carrillo Montoya3, Chang-Seong Moon +2154 more•Institutions (149)
TL;DR: The first direct search for lepton-flavour-violating decays of the recently discovered Higgs boson (H) is described in this paper, where the search is performed in the H→μτ_e and H→mτ_h channels, where τeτe and τ_h are tau leptons reconstructed in the electronic and hadronic decay channels, respectively.
285 citations
Authors
Showing all 27508 results
Name | H-index | Papers | Citations |
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Jasvinder A. Singh | 176 | 2382 | 223370 |
Hongfang Liu | 166 | 2356 | 156290 |
Ian J. Deary | 166 | 1795 | 114161 |
Yongsun Kim | 156 | 2588 | 145619 |
Dong-Chul Son | 138 | 1370 | 98686 |
Simon C. Watkins | 135 | 950 | 68358 |
Kenichi Hatakeyama | 134 | 1731 | 102438 |
Conor Henderson | 133 | 1387 | 88725 |
Peter R Hobson | 133 | 1590 | 94257 |
Tulika Bose | 132 | 1285 | 88895 |
Helen F Heath | 132 | 1185 | 89466 |
James Rohlf | 131 | 1215 | 89436 |
Panos A Razis | 130 | 1287 | 90704 |
David B. Allison | 129 | 836 | 69697 |
Eduardo Marbán | 129 | 579 | 49586 |