University of Alabama

About: University of Alabama is a education organization based out in Tuscaloosa, Alabama, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 27323 authors who have published 48609 publications receiving 1565337 citations. The organization is also known as: Alabama & Bama.

Flood frequency in China's Poyang Lake region: trends and teleconnections

Abstract: Poyang Lake in Jiangxi Province is the largest freshwater lake in China and is historically a region of significant floods. Annual events of peak lake stage and of severe floods have increased dramatically during the past few decades. This trend is related primarily to levee construction at the periphery of the lake and along the middle of the Changjiang (Yangtze River), which protects a large rural population. These levees reduce the area formerly available for floodwater storage resulting in higher lake stages during the summer flood season and catastrophic levee failures. The most severe floods in the Poyang Lake since 1950, and ranked in descending order of severity, occurred in 1998, 1995, 1954, 1983, 1992, 1973, and 1977. All of these floods occurred during or immediately following El Ni˜ no events, which are directly linked to rainfall in central China. The 2-year recurrence interval for maximum annual lake stage during El Ni˜ no years is 1.2 m higher than during non-El Ni˜ no years. The 10-year recurrence interval is 1.4 m higher during El Ni˜ no years than during non-El Ni˜ no years. Copyright  2006 Royal Meteorological Society.

Expanding Entrepreneurial Cognition's Toolbox: Potential Contributions from the Field of Cognitive Science

Abstract: Several measures and methods developed by the field of cognitive science may prove useful to researchers investigating various aspects of entrepreneurial cognition. These techniques include ones th...

Effects of exercise modalities on arterial stiffness and wave reflection: a systematic review and meta-analysis of randomized controlled trials.

Abstract: Background and Objectives Physical activity is associated with lower cardiovascular and all-cause mortality However, the effects of different exercise modalities on arterial stiffness are currently unclear Our objectives were to investigate the effects of exercise modalities (aerobic, resistance or combined) on pulse wave velocity (PWV) and augmentation index (AIx), and to determine whether the effects on these indices differed according to the participants' or exercise characteristics

Refined structures of mouse P‐glycoprotein

Abstract: The recently determined C. elegans P-glycoprotein (Pgp) structure revealed significant deviations compared to the original mouse Pgp structure, which suggested possible misinterpreta- tions in the latter model. To address this concern, we generated an experimental electron density map from single-wavelength anomalous dispersion phasing of an original mouse Pgp dataset to 3.8 Aresolution. The map exhibited significantly more detail compared to the original MAD map and revealed several regions of the structure that required de novo model building. The improved drug-free structure was refined to 3.8 Aresolution with a 9.4 and 8.1% decrease in Rwork and Rfree, respectively, (Rwork 521.2%, Rfree 526.6%) and a significant improvement in protein geometry. The improved mouse Pgp model contains ~95% of residues in the favorable Ramachandran region compared to only 57% for the original model. The registry of six transmembrane helices was cor- rected, revealing amino acid residues involved in drug binding that were previously unrecognized. Registry shifts (rotations and translations) for three transmembrane (TM)4 and TM5 and the addi- tion of three N-terminal residues were necessary, and were validated with new mercury labeling and anomalous Fourier density. The corrected position of TM4, which forms the frame of a portal for drug entry, had backbone atoms shifted > 6Afrom their original positions. The drug transloca- tion pathway of mouse Pgp is 96% identical to human Pgp and is enriched in aromatic residues that likely play a collective role in allowing a high degree of polyspecific substrate recognition.