Institution
University of Fribourg
Education•Fribourg, Freiburg, Switzerland•
About: University of Fribourg is a education organization based out in Fribourg, Freiburg, Switzerland. It is known for research contribution in the topics: Population & Context (language use). The organization has 6040 authors who have published 14975 publications receiving 542500 citations. The organization is also known as: UNIFR & Universität Freiburg.
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407 citations
TL;DR: It is shown that enhanced passive Ca2+ transport in the proximal tubule rather than active Ca2 + transport in distal convolution explains thiazide-induced hypocalciuria, and that Trpm6 downregulation may represent a general mechanism involved in the pathogenesis of hypomagnesemia accompanying NCC inhibition or inactivation.
Abstract: Thiazide diuretics enhance renal Na+ excretion by blocking the Na+-Cl- cotransporter (NCC), and mutations in NCC result in Gitelman syndrome. The mechanisms underlying the accompanying hypocalciuria and hypomagnesemia remain debated. Here, we show that enhanced passive Ca2+ transport in the proximal tubule rather than active Ca2+ transport in distal convolution explains thiazide-induced hypocalciuria. First, micropuncture experiments in mice demonstrated increased reabsorption of Na+ and Ca2+ in the proximal tubule during chronic hydrochlorothiazide (HCTZ) treatment, whereas Ca2+ reabsorption in distal convolution appeared unaffected. Second, HCTZ administration still induced hypocalciuria in transient receptor potential channel subfamily V, member 5-knockout (Trpv5-knockout) mice, in which active distal Ca2+ reabsorption is abolished due to inactivation of the epithelial Ca2+ channel Trpv5. Third, HCTZ upregulated the Na+/H+ exchanger, responsible for the majority of Na+ and, consequently, Ca2+ reabsorption in the proximal tubule, while the expression of proteins involved in active Ca2+ transport was unaltered. Fourth, experiments addressing the time-dependent effect of a single dose of HCTZ showed that the development of hypocalciuria parallels a compensatory increase in Na+ reabsorption secondary to an initial natriuresis. Hypomagnesemia developed during chronic HCTZ administration and in NCC-knockout mice, an animal model of Gitelman syndrome, accompanied by downregulation of the epithelial Mg2+ channel transient receptor potential channel subfamily M, member 6 (Trpm6). Thus, Trpm6 downregulation may represent a general mechanism involved in the pathogenesis of hypomagnesemia accompanying NCC inhibition or inactivation.
407 citations
University of Oslo1, Central Institution for Meteorology and Geodynamics2, Russian Academy of Sciences3, University Centre in Svalbard4, Mongolian Academy of Sciences5, University of Fribourg6, University of Copenhagen7, University of Alaska Fairbanks8, University of Ottawa9, Queen's University10, Memorial University of Newfoundland11, Chinese Academy of Sciences12
TL;DR: In this article, an equilibrium state model for the temperature at the top of the permafrost (TTOP model) for the 2000-2016 period, driven by remotely-sensed land surface temperatures, down-scaled ERA-Interim climate reanalysis data, tundra wetness classes and landcover map from the ESA Landcover Climate Change Initiative (CCI), was employed.
404 citations
TL;DR: The results showed that participants using the highly appealing phone rated their appliance as being more usable than participants operating the unappealing model, and the visual appearance of the phone had a positive effect on performance, leading to reduced task completion times for the attractive model.
397 citations
University of Geneva1, University of Helsinki2, Katholieke Universiteit Leuven3, University of Washington4, University of Wisconsin-Madison5, German Cancer Research Center6, Heidelberg University7, University of Nottingham8, VU University Amsterdam9, University of California, Irvine10, University of California, San Francisco11, French Institute of Health and Medical Research12, Harvard University13, Maine Medical Center14, University of Turin15, National Institutes of Health16, University of Texas Southwestern Medical Center17, University of Lausanne18, University of Missouri19, École Polytechnique Fédérale de Lausanne20, Uppsala University21, University of Arkansas for Medical Sciences22, University of Bern23, University of Virginia24, Imperial College London25, University of California, San Diego26, University College London27, Flanders Institute for Biotechnology28, University of Oxford29, University of California, Los Angeles30, University of Texas MD Anderson Cancer Center31, University of Toronto32, University of Illinois at Chicago33, University of Amsterdam34, George Washington University35, University of Liège36, University of Eastern Finland37, Ludwig Institute for Cancer Research38, Indiana University39, University of Edinburgh40, Maastricht University41, Loyola University Medical Center42, National Scientific and Technical Research Council43, University of Bari44, University of Fribourg45, Ohio State University46, University of Melbourne47, University of Antwerp48, University of Münster49
TL;DR: In vivo, ex vivo, and in vitro bioassays that are available for the evaluation of angiogenesis are described and critical aspects that are relevant for their execution and proper interpretation are highlighted.
Abstract: The formation of new blood vessels, or angiogenesis, is a complex process that plays important roles in growth and development, tissue and organ regeneration, as well as numerous pathological conditions. Angiogenesis undergoes multiple discrete steps that can be individually evaluated and quantified by a large number of bioassays. These independent assessments hold advantages but also have limitations. This article describes in vivo, ex vivo, and in vitro bioassays that are available for the evaluation of angiogenesis and highlights critical aspects that are relevant for their execution and proper interpretation. As such, this collaborative work is the first edition of consensus guidelines on angiogenesis bioassays to serve for current and future reference.
397 citations
Authors
Showing all 6204 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Jens Nielsen | 149 | 1752 | 104005 |
| Sw. Banerjee | 146 | 1906 | 124364 |
| Hans Peter Beck | 143 | 1134 | 91858 |
| Patrice Nordmann | 127 | 790 | 67031 |
| Abraham Z. Snyder | 125 | 329 | 91997 |
| Csaba Szabó | 123 | 958 | 61791 |
| Robert Edwards | 121 | 775 | 74552 |
| Laurent Poirel | 117 | 621 | 53680 |
| Thomas Münzel | 116 | 1055 | 57716 |
| David G. Amaral | 112 | 302 | 49094 |
| F. Blanc | 107 | 1514 | 58418 |
| Markus Stoffel | 102 | 620 | 50796 |
| Vincenzo Balzani | 101 | 476 | 45722 |
| Enrico Bertini | 99 | 865 | 38167 |
| Sandeep Kumar | 94 | 1563 | 38652 |