Institution
University of Kansas
Education•Lawrence, Kansas, United States•
About: University of Kansas is a education organization based out in Lawrence, Kansas, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 38183 authors who have published 81381 publications receiving 2986312 citations. The organization is also known as: KU & Univ of Kansas.
Topics: Population, Poison control, Health care, Context (language use), Cancer
Papers published on a yearly basis
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TL;DR: Inhibition of DNMTs has demonstrated reduction in tumor formation in part through the increased expression of tumor suppressor genes, and this represents a promising approach for the prevention and treatment of many cancers.
Abstract: Cancer is the second leading cause of death in US. Despite the emergence of new, targeted agents, and the use of various therapeutic combinations, none of the available treatment options are curative in patients with advanced cancer. Epigenetic alterations are increasingly recognized as valuable targets for the development of cancer therapies. DNA methylation at the 5-position of cytosine, catalyzed by DNA methyltransferases (DNMTs), is the predominant epigenetic modification in mammals. DNMT1, the major enzyme responsible for maintenance of the DNA methylation pattern is located at the replication fork and methylates newly biosynthesized DNA. DNMT2 or TRDMT1, the smallest mammalian DNMT is believed to participate in the recognition of DNA damage, DNA recombination, and mutation repair. It is composed solely of the C-terminal domain, and does not possess the regulatory N-terminal region. The levels of DNMTs, especially those of DNMT3B, DNMT3A, and DNMT3L, are often increased in various cancer tissues and cell lines, which may partially account for the hypermethylation of promoter CpG-rich regions of tumor suppressor genes in a variety of malignancies. Moreover, it has been shown to function in self-renewal and maintenance of colon cancer stem cells and need to be studied in several cancers. Inhibition of DNMTs has demonstrated reduction in tumor formation in part through the increased expression of tumor suppressor genes. Hence, DNMTs can potentially be used as anti-cancer targets. Dietary phytochemicals also inhibit DNMTs and cancer stem cells; this represents a promising approach for the prevention and treatment of many cancers.
398 citations
TL;DR: In this paper, the authors discuss the role of nitrogen and phosphorus in the degradation of rivers and streams in many parts of the world, including the USA and Canada, and their role in this process.
Abstract: Flowing waters receive substantial nutrient inputs, including both nitrogen (N) and phosphorus (P), in many parts of the world. Eutrophication science for rivers and streams has unfortunately lagge...
398 citations
15 Jul 2008
398 citations
University of Pittsburgh1, University of Edinburgh2, University of Birmingham3, Baylor University Medical Center4, University of California, San Francisco5, Queen Elizabeth Hospital Birmingham6, Harvard University7, Royal Prince Alfred Hospital8, Cleveland Clinic9, Oslo University Hospital10, Kyoto University11, University Health Network12, Mayo Clinic13, Mount Sinai Hospital14, Icahn School of Medicine at Mount Sinai15, University of São Paulo16, University of Cambridge17, Columbia University18, Cincinnati Children's Hospital Medical Center19, Universidade Federal do Rio Grande do Sul20, Loma Linda University21, Ain Shams University22, Hospital of the University of Pennsylvania23, University Medical Center Groningen24, Toronto General Hospital25, University of Chicago26, Beni-Suef University27, Kobe University28, Temple University29, Lahey Hospital & Medical Center30, Duke University31, University of North Carolina at Chapel Hill32, University of California, Los Angeles33, Cliniques Universitaires Saint-Luc34, Northwestern University35, St. Joseph's Hospital and Medical Center36, Sahlgrenska University Hospital37, Beth Israel Deaconess Medical Center38, University of Kansas39, Hadassah Medical Center40, University of Southern California41, University of Miami42, Dokuz Eylül University43, University of Pennsylvania44, University of Alberta Hospital45, University of Texas Medical Branch46, University of Rome Tor Vergata47, University of Patras48, Karolinska University Hospital49, Tulane University50
TL;DR: New recommendations for complement component 4d tissue staining and interpretation, staging liver allograft fibrosis, and findings related to immunosuppression minimization are included.
397 citations
TL;DR: In this paper, an essential cell division protein that is localized to the leading edge of the bacterial septum in a cytokinetic ring was incubated in vitro by electron microscopy and showed a guanine nucleotide-dependent assembly into protein filaments.
Abstract: FtsZ is an essential cell division protein that is localized to the leading edge of the bacterial septum in a cytokinetic ring. It contains the tubulin signature motif and is a GTP binding protein with a GTPase activity. Further comparison of FtsZ with eukaryotic tubulins revealed some additional sequence similarities, perhaps indicating a similar GTP binding site. Examination of FtsZ incubated in vitro by electron microscopy revealed a guanine nucleotide-dependent assembly into protein filaments, supporting the hypothesis that the FtsZ ring is formed through self-assembly. FtsZ3, which is unable to bind GTP, does not polymerize, whereas FtsZ2, which binds GTP but is deficient in GTP hydrolysis, is capable of polymerization.
397 citations
Authors
Showing all 38401 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Gordon H. Guyatt | 231 | 1620 | 228631 |
| Krzysztof Matyjaszewski | 169 | 1431 | 128585 |
| Wei Li | 158 | 1855 | 124748 |
| David Tilman | 158 | 340 | 149473 |
| Tomas Hökfelt | 158 | 1033 | 95979 |
| Pete Smith | 156 | 2464 | 138819 |
| Daniel J. Rader | 155 | 1026 | 107408 |
| Melody A. Swartz | 148 | 1304 | 103753 |
| Kevin Murphy | 146 | 728 | 120475 |
| Carlo Rovelli | 146 | 1502 | 103550 |
| Stephen Sanders | 145 | 1385 | 105943 |
| Marco Zanetti | 145 | 1439 | 104610 |
| Andrei Gritsan | 143 | 1531 | 135398 |
| Gunther Roland | 141 | 1471 | 100681 |
| Joseph T. Hupp | 141 | 731 | 82647 |