Institution
University of Nebraska–Lincoln
Education•Lincoln, Nebraska, United States•
About: University of Nebraska–Lincoln is a education organization based out in Lincoln, Nebraska, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 28059 authors who have published 61544 publications receiving 2139104 citations. The organization is also known as: Nebraska & UNL.
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TL;DR: Due to the internalization capacity of the F127250 formulation, its curcumin-loaded formulation (F 127250-CUR) exhibited almost equivalent inhibition effects on A2780CP (ovarian), MDA-MB-231 (breast), and PC-3 (prostate) cancer cells even thoughCurcumin release was only 40%.
394 citations
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University of Copenhagen1, Montana State University2, Humboldt University of Berlin3, Max Planck Society4, University of Toulouse5, Alpen-Adria-Universität Klagenfurt6, Dresden University of Technology7, Woods Hole Research Center8, Institut national de la recherche agronomique9, University of Göttingen10, Northern Arizona University11, Potsdam Institute for Climate Impact Research12, Finnish Meteorological Institute13, Université catholique de Louvain14, Wageningen University and Research Centre15, United States Department of Agriculture16, Technical University of Denmark17, University of Aveiro18, Centre national de la recherche scientifique19, University of Nebraska–Lincoln20, VU University Amsterdam21
TL;DR: In this paper, the authors investigated the biophysical effects of temperate land-management changes and revealed a net warming effect of similar magnitude to that driven by changing land cover, and found that potential surface cooling from increased albedo is typically offset by warming from decreased sensible heat fluxes.
Abstract: The direct effects of land-cover change on surface climate are increasingly well understood, but fewer studies have investigated the consequences of the trend towards more intensive land management practices. Now, research investigating the biophysical effects of temperate land-management changes reveals a net warming effect of similar magnitude to that driven by changing land cover. Anthropogenic changes to land cover (LCC) remain common, but continuing land scarcity promotes the widespread intensification of land management changes (LMC) to better satisfy societal demand for food, fibre, fuel and shelter1. The biophysical effects of LCC on surface climate are largely understood2,3,4,5, particularly for the boreal6 and tropical zones7, but fewer studies have investigated the biophysical consequences of LMC; that is, anthropogenic modification without a change in land cover type. Harmonized analysis of ground measurements and remote sensing observations of both LCC and LMC revealed that, in the temperate zone, potential surface cooling from increased albedo is typically offset by warming from decreased sensible heat fluxes, with the net effect being a warming of the surface. Temperature changes from LMC and LCC were of the same magnitude, and averaged 2 K at the vegetation surface and were estimated at 1.7 K in the planetary boundary layer. Given the spatial extent of land management (42–58% of the land surface) this calls for increasing the efforts to integrate land management in Earth System Science to better take into account the human impact on the climate8.
394 citations
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TL;DR: The environmental fate ofDCF in different compartments such as soil and water has been addressed with an overview of current treatment methods and the toxicity concerns regarding DCF in aquatic as well as terrestrial environment along with an introduction to the metabolites of DCF through consumption and abiotic degradation routes are discussed.
394 citations
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TL;DR: The purpose of this article was to provide a tutorial for performing cross-sectional and longitudinal analyses using this popular software platform, and borrowed heavily from Singer’s overview of SAS PROC MixED, duplicating her analyses using the SPSS MIXED procedure.
Abstract: Beginning with Version 11, SPSS implemented the MIXED procedure, which is capable of performing many common hierarchical linear model analyses. The purpose of this article was to provide a tutorial for performing cross-sectional and longitudinal analyses using this popular software platform. In doing so, the authors borrowed heavily from Singer’s overview of SAS PROC MIXED, duplicating her analyses using the SPSS MIXED procedure.
393 citations
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Johns Hopkins University1, University of Utah2, Fox Chase Cancer Center3, University of Michigan4, Roswell Park Cancer Institute5, Brigham and Women's Hospital6, Duke University7, Washington University in St. Louis8, City of Hope National Medical Center9, Vanderbilt University10, University of California, San Francisco11, University Of Tennessee System12, University of Nebraska–Lincoln13, University of Texas MD Anderson Cancer Center14, Memorial Sloan Kettering Cancer Center15, Harvard University16, Stanford University17, Seattle Cancer Care Alliance18, University of Alabama19, Ohio State University20, Northwestern University21, University of South Florida22
TL;DR: These NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) focus on malignant pleural mesothelioma (MPM), which is the most common type.
Abstract: malignant pleural mesothelioma is a relatively uncommon disease associated with asbestos exposure. its incidence increased markedly following the widespread mining and use of asbestos in many industries. the legal aspects regarding compensation cases for those who have developed this disease has raised its profile in the media, but also compounds the stress of diagnosis for patients. it has an insidious onset and may clinically and pathologically mimic other benign or malignant processes, complicating diagnosis. radical surgery may be used for a highly selected population of malignant pleural mesothelioma patients in the context of multimodality treatment in an experienced thoracic surgical centre, but there is no randomised evidence to support its benefit. in most cases surgery is used to treat symptoms or obtain tissue for diagnosis. Combination of a platinum agent and pemetrexed is now widely used and shown to prolong life. other treatments including radiotherapy, analgesics and supportive interventions are an integral part of the treatment of this disease. Further research is being undertaken on promising novel therapies for use in this disease, which will be discussed in this review. malignant pleural mesothelioma (mpm) is a neoplasm originating from mesothelial cells, which form the membranes surrounding the lung cavities. it is currently a disease mainly of the industrialised world, closely linked to asbestos exposure.1 seldom diagnosed prior to the advent of widespread asbestos mining in the early to mid twentieth century, it has risen in incidence over the last five decades.2, 3 according to the most recent australian institute of health and Welfare data, in 2009 there were 666 cases of malignant mesothelioma diagnosed in australia.4 this review will provide a brief overview of the diagnosis, current treatment modalities and some novel systemic treatment strategies that have been explored in mpm. Asbestos and malignant mesothelioma mpm is a disease with particular relevance to australia. Asbestos was first mined in Australia in the 1880s near Jones Creek, a town in nsW.5 it was not until the late 1940s when the insulating properties of asbestos rendered it a useful product in the building industry during the post war building boom, and subsequent demand for asbestos saw mining production rise exponentially in mines in nsW, tasmania, south australia and Western australia.5 there has also been widespread exposure within the building and transport industries in which asbestos was broadly utilised.6 Asbestos mining ended in Australia in 1983, and it is expected that malignant mesothelioma related to occupational exposure will plateau in the coming decade. in a Western Australian study, however, a significant increase was noted in the number of people being diagnosed with malignant meosthelioma whose only exposure to asbestos must have occurred in a non-occupational setting (most likely during home maintenance and renovation). Between 2005 and 2008, 8% of males and 5% of females diagnosed with malignant mesothelioma in this series reported non-occupational exposure as their only exposure to asbestos.6 these observations ask for confirmation in a case-controlled epidemiological study.
393 citations
Authors
Showing all 28272 results
Name | H-index | Papers | Citations |
---|---|---|---|
Donald P. Schneider | 242 | 1622 | 263641 |
Suvadeep Bose | 154 | 960 | 129071 |
David D'Enterria | 150 | 1592 | 116210 |
Aaron Dominguez | 147 | 1968 | 113224 |
Gregory R Snow | 147 | 1704 | 115677 |
J. S. Keller | 144 | 981 | 98249 |
Andrew Askew | 140 | 1496 | 99635 |
Mitchell Wayne | 139 | 1810 | 108776 |
Kenneth Bloom | 138 | 1958 | 110129 |
P. de Barbaro | 137 | 1657 | 102360 |
Randy Ruchti | 137 | 1832 | 107846 |
Ia Iashvili | 135 | 1676 | 99461 |
Yuichi Kubota | 133 | 1695 | 98570 |
Ilya Kravchenko | 132 | 1366 | 93639 |
Andrea Perrotta | 131 | 1380 | 85669 |