CAS proteins in normal and pathological cell growth control
TLDR
This review will explore the roles of the CAS proteins in normal and pathological states in the context of the many mechanistic insights into CAS protein function that have emerged in the past decade.Abstract:
Proteins of the CAS (Crk-associated substrate) family (BCAR1/p130Cas, NEDD9/HEF1/Cas-L, EFS/SIN and CASS4/HEPL) are integral players in normal and pathological cell biology. CAS proteins act as scaffolds to regulate protein complexes controlling migration and chemotaxis, apoptosis, cell cycle, and differentiation, and have more recently been linked to a role in progenitor cell function. Reflecting these complex functions, over-expression of CAS proteins has now been strongly linked to poor prognosis and increased metastasis in cancer, as well as resistance to first-line chemotherapeutics in multiple tumor types including breast and lung cancers, glioblastoma, and melanoma. Further, CAS proteins have also been linked to additional pathological conditions including inflammatory disorders, Alzheimer’s and Parkinson’s disease, as well as developmental defects. This review will explore the roles of the CAS proteins in normal and pathological states in the context of the many mechanistic insights into CAS protein function that have emerged in the past decade.read more
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A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer
Ali Amin Al Olama,Zsofia Kote-Jarai,Sonja I. Berndt,David V. Conti,Fredrick R. Schumacher,Ying Han,Sara Benlloch,Dennis J. Hazelett,Zhaoming Wang,Ed Saunders,Daniel Leongamornlert,Sara Lindström,Sara Jugurnauth-Little,Tokhir Dadaev,Malgorzata Tymrakiewicz,Daniel O. Stram,Kristin A. Rand,Peggy Wan,Alex Stram,Xin Sheng,Loreall Pooler,Karen Park,Lucy Xia,Jonathan Tyrer,Laurence N. Kolonel,Loic Le Marchand,Robert N. Hoover,Mitchell J. Machiela,Merideth Yeager,Laurie Burdette,Charles C. Chung,Amy K. Hutchinson,Kai Yu,Chee Goh,Mahbubl Ahmed,Koveela Govindasami,Michelle Guy,Teuvo L.J. Tammela,Anssi Auvinen,Tiina Wahlfors,Johanna Schleutker,Tapio Visakorpi,Katri A. Leinonen,Jianfeng Xu,Markus Aly,Jenny L Donovan,Ruth C. Travis,Timothy J. Key,Afshan Siddiq,Federico Canzian,Kay-Tee Khaw,Atsushi Takahashi,Michiaki Kubo,Paul D.P. Pharoah,Nora Pashayan,Maren Weischer,Børge G. Nordestgaard,Sune F. Nielsen,Peter Klarskov,Martin Andreas Røder,Peter Iversen,Stephen N. Thibodeau,Shannon K. McDonnell,Daniel J. Schaid,Janet L. Stanford,Janet L. Stanford,Suzanne Kolb,Sarah K. Holt,Beatrice S. Knudsen,Antonio Hurtado Coll,Susan M. Gapstur,W. Ryan Diver,Victoria L. Stevens,Christiane Maier,Manuel Luedeke,Kathleen Herkommer,Antje E. Rinckleb,Sara S. Strom,Curtis A. Pettaway,Edward D. Yeboah,Edward D. Yeboah,Yao Tettey,Yao Tettey,Richard B. Biritwum,Richard B. Biritwum,Andrew A. Adjei,Andrew A. Adjei,Evelyn Tay,Evelyn Tay,Ann Truelove,Shelley Niwa,Anand P. Chokkalingam,Lisa A. Cannon-Albright,Lisa A. Cannon-Albright,Cezary Cybulski,Dominika Wokołorczyk,Wojciech Kluźniak,Jong Y. Park,Thomas A. Sellers,Hui-Yi Lin,William B. Isaacs,Alan W. Partin,Hermann Brenner,Aida Karina Dieffenbach,Christa Stegmaier,Constance Chen,Edward Giovannucci,Jing Ma,Meir J. Stampfer,Kathryn L. Penney,Lorelei A. Mucci,Esther M. John,Esther M. John,Sue A. Ingles,Rick A. Kittles,Adam B. Murphy,Hardev Pandha,Agnieszka Michael,Andrzej M. Kierzek,William J. Blot,Lisa B. Signorello,Wei Zheng,Demetrius Albanes,Jarmo Virtamo,Stephanie J. Weinstein,Barbara Nemesure,John D. Carpten,Cristina Leske,Suh-Yuh Wu,Anselm Hennis,Anselm Hennis,Adam S. Kibel,Benjamin A. Rybicki,Christine Neslund-Dudas,Ann W. Hsing,Ann W. Hsing,Lisa Chu,Lisa Chu,Phyllis J. Goodman,Eric A. Klein,S. Lilly Zheng,Jyotsna Batra,Judith A. Clements,Amanda B. Spurdle,Manuel R. Teixeira,Manuel R. Teixeira,Paula Paulo,Sofia Maia,Chavdar Slavov,Radka Kaneva,Vanio Mitev,John S. Witte,Graham Casey,Elizabeth M. Gillanders,Daniella Seminara,Elio Riboli,Freddie C. Hamdy,Gerhard A. Coetzee,Qiyuan Li,Matthew L. Freedman,David J. Hunter,Kenneth Muir,Kenneth Muir,Henrik Grönberg,David E. Neal,David E. Neal,Melissa C. Southey,Graham G. Giles,Graham G. Giles,Gianluca Severi,Gianluca Severi,Michael B. Cook,Hidewaki Nakagawa,Fredrik Wiklund,Peter Kraft,Stephen J. Chanock,Brian E. Henderson,Douglas F. Easton,Rosalind A. Eeles,Christopher A. Haiman +179 more
TL;DR: These findings provide new regions for investigation into the pathogenesis of prostate cancer and demonstrate the usefulness of combining ancestrally diverse populations to discover risk loci for disease.
Journal ArticleDOI
Aurora A kinase (AURKA) in normal and pathological cell division.
TL;DR: The mitotic and non-mitotic functions of Aurora A are reviewed, Aurora A regulation in the context of protein structural information is discussed, and progress in understanding and inhibiting Aurora A in cancer is evaluated.
Journal ArticleDOI
Integrin signalling adaptors: not only figurants in the cancer story
TL;DR: In this paper, the relevance of adaptor proteins in signalling that originates from integrin-mediated cell-extracellular matrix (ECM) adhesion and growth factor stimulation in the context of cell transformation and tumour progression is discussed.
Integrin signalling adaptors: not only figurants in the cancer story. Nat Rev Cancer.
TL;DR: The contribution of p130 Crk-associated substrate, neural precursor cell expressed, developmentally down-regulated 9, CRK and the integrin-linked kinase (ILK)–pinch–parvin (IPP) complex to cancer, along with the more recently identified p140 Cas-associated protein are highlighted.
Journal ArticleDOI
Genome-wide association and linkage identify modifier loci of lung disease severity in cystic fibrosis at 11p13 and 20q13.2.
Fred A. Wright,Lisa J. Strug,Vishal K. Doshi,Clayton W. Commander,Scott M. Blackman,Lei Sun,Yves Berthiaume,David J. Cutler,Andreea L. Cojocaru,J. Michael Collaco,Mary Corey,Ruslan Dorfman,Katrina A.B. Goddard,Deanna M. Green,Jack W. Kent,Ethan M. Lange,Seunggeun Lee,Weili Li,Jingchun Luo,Gregory Mayhew,Kathleen M. Naughton,Rhonda G. Pace,Peter D. Paré,Johanna M. Rommens,Andrew J. Sandford,Jaclyn R. Stonebraker,Wei Sun,Chelsea Taylor,Lori L. Vanscoy,Fei Zou,John Blangero,Julian Zielenski,Wanda K. O'Neal,Mitchell L. Drumm,Peter R. Durie,Michael R. Knowles,Garry R. Cutting +36 more
TL;DR: The authors' findings provide insight into the causes of variation in lung disease severity in cystic fibrosis and suggest new therapeutic targets for this life-limiting disorder.
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