Open Access
Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex
Silvana Konermann,Mark D. Brigham,Alexandro E. Trevino,Julia Joung,Clea Barcena,Patrick D. Hsu,Naomi Habib,Jonathan S. Gootenberg,Hiroshi Nishimasu,Osamu Nureki,Feng Zhang,Omar O. Abudayyeh +11 more
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The article was published on 2016-05-22 and is currently open access. It has received 1792 citations till now. The article focuses on the topics: CRISPR.read more
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Cell-specific CRISPR/Cas9 activation by microRNA-dependent expression of anti-CRISPR proteins
Mareike D. Hoffmann,Mareike D. Hoffmann,Sabine Aschenbrenner,Sabine Aschenbrenner,Stefanie Grosse,Kleopatra Rapti,Kleopatra Rapti,Claire Domenger,Claire Domenger,Julia Fakhiri,Julia Fakhiri,Manuel Mastel,Roland Eils,Roland Eils,Dirk Grimm,Dirk Grimm,Dominik Niopek +16 more
TL;DR: The Cas-ON switch should facilitate cell-specific activation of any CRISPR/Cas orthologue, for which a potent anti-CRISPR protein is known, and is adapted to the smaller and more target-specific Neisseria meningitidis (Nme)Cas9 orthologue and its cognate inhibitors AcrIIC1 and Acr IIC3.
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High-resolution temporal transcriptome sequencing unravels ERF and WRKY as the master players in the regulatory networks underlying sesame responses to waterlogging and recovery.
Linhai Wang,Komivi Dossa,Jun You,Yanxin Zhang,Donghua Li,Rong Zhou,Jingyin Yu,Xin Wei,Xiaodong Zhu,Shiyang Jiang,Yuan Gao,Marie A. Mmadi,Xiurong Zhang +12 more
TL;DR: This study unveils the architecture and dynamic regulation of the waterlogging/drainage response in a non-model crop and helps formulate new hypotheses on stress sensing, signaling and sophisticated adaptive responses.
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Anlotinib can overcome acquired resistance to EGFR-TKIs via FGFR1 signaling in non-small cell lung cancer without harboring EGFR T790M mutation.
Zengzhi Lian,Wenwen Du,Yang Zhang,Yulong Fu,Ting Liu,Anqi Wang,Tingting Cai,Jianjie Zhu,Yuanyuan Zeng,Zeyi Liu,Jian-An Huang +10 more
TL;DR: Although many studies have defined mechanisms of resistance to EGFR‐TKIs, acquired resistance remains the major limitation of monotherapy with EGFR-TKis.
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Neuro-Immuno-Gene- and Genome-Editing-Therapy for Alzheimer's Disease: Are We There Yet?
Sudhanshu P. Raikwar,Sudhanshu P. Raikwar,Ramasamy Thangavel,Ramasamy Thangavel,Iuliia Dubova,Mohammad Ejaz Ahmed,Mohammad Ejaz Ahmed,Pushpavathi Govindhasamy Selvakumar,Pushpavathi Govindhasamy Selvakumar,Duraisamy Kempuraj,Duraisamy Kempuraj,Smita Zaheer,Shankar S. Iyer,Shankar S. Iyer,Asgar Zaheer,Asgar Zaheer +15 more
TL;DR: It is hoped that the quantum leap in the scientific advancements and improved funding will bolster novel concepts that will propel the momentum toward a trajectory leading to a robust AD patient-specific next generation precision medicine with improved cognitive function and excellent life quality.
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Volatile Semiochemical Mediated Plant Defense in Cereals: A Novel Strategy for Crop Protection
Amanuel Tamiru,Zeyaur R. Khan +1 more
TL;DR: The practical examples discussed in this review paper demonstrate the real prospect of exploiting an inducible and constitutive plant volatile semiochemicals for developing novel and ecologically-sustainable pest management strategies to protect cereal crops from damaging insect pests.
References
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The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity
Jordi Barretina,Giordano Caponigro,Nicolas Stransky,Kavitha Venkatesan,Adam A. Margolin,Adam A. Margolin,Sungjoon Kim,Christine D. Wilson,Joseph Lehar,Gregory V. Kryukov,Dmitriy Sonkin,Anupama Reddy,Manway Liu,Lauren Murray,Michael F. Berger,Michael F. Berger,John Monahan,Paula Morais,Jodi Meltzer,Adam Korejwa,Judit Jané-Valbuena,Judit Jané-Valbuena,Felipa A. Mapa,Joseph Thibault,Eva Bric-Furlong,Pichai Raman,Aaron Shipway,Ingo H. Engels,Jill Cheng,Guoying K. Yu,Jianjun Yu,Peter Aspesi,Melanie de Silva,Kalpana Jagtap,Michael D. Jones,Li Wang,Charlie Hatton,Emanuele Palescandolo,Supriya Gupta,Scott Mahan,Carrie Sougnez,Robert C. Onofrio,Ted Liefeld,Laura E. MacConaill,Wendy Winckler,Michael R. Reich,Nanxin Li,Jill P. Mesirov,Stacey Gabriel,Gad Getz,Kristin G. Ardlie,Vivien W. Chan,Vic E. Myer,Barbara L. Weber,Jeffrey A. Porter,Markus Warmuth,Peter Finan,Jennifer L. Harris,Matthew Meyerson,Matthew Meyerson,Todd R. Golub,Michael Morrissey,William R. Sellers,Robert Schlegel,Levi A. Garraway,Levi A. Garraway +65 more
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Molecular signatures database (MSigDB) 3.0
Arthur Liberzon,Aravind Subramanian,Reid M. Pinchback,Helga Thorvaldsdottir,Pablo Tamayo,Jill P. Mesirov +5 more
TL;DR: A new version of the database, MSigDB 3.0, is reported, with over 6700 gene sets, a complete revision of the collection of canonical pathways and experimental signatures from publications, enhanced annotations and upgrades to the web site.