Journal ArticleDOI
Graphene-Based Interfaces Do Not Alter Target Nerve Cells
Alessandra Fabbro,Alessandra Fabbro,Denis Scaini,Denis Scaini,Verónica León,Ester Vázquez,Giada Cellot,G. Privitera,Lucia Lombardi,Felice Torrisi,Flavia Tomarchio,Francesco Bonaccorso,Francesco Bonaccorso,Susanna Bosi,Andrea C. Ferrari,Laura Ballerini,Laura Ballerini,Maurizio Prato,Maurizio Prato +18 more
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TLDR
Graphene-based substrates (GBSs) are shown to be permissive interfaces, even when uncoated by cell adhesion layers, retaining unaltered neuronal signaling properties, thus being suitable for carbon-based neural prosthetic devices.Abstract:
Neural-interfaces rely on the ability of electrodes to transduce stimuli into electrical patterns delivered to the brain. In addition to sensitivity to the stimuli, stability in the operating conditions and efficient charge transfer to neurons, the electrodes should not alter the physiological properties of the target tissue. Graphene is emerging as a promising material for neuro-interfacing applications, given its outstanding physico-chemical properties. Here, we use graphene-based substrates (GBSs) to interface neuronal growth. We test our GBSs on brain cell cultures by measuring functional and synaptic integrity of the emerging neuronal networks. We show that GBSs are permissive interfaces, even when uncoated by cell adhesion layers, retaining unaltered neuronal signaling properties, thus being suitable for carbon-based neural prosthetic devices.read more
Citations
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Journal ArticleDOI
Peripheral Neuron Survival and Outgrowth on Graphene
TL;DR: In this paper, a nano-resolved analysis of polymeric coatings on graphene and combine optical microscopy and viability assays to assess the material cytocompatibility and influence on differentiation was performed.
Journal ArticleDOI
Functional Graphene Nanomaterials Based Architectures: Biointeractions, Fabrications, and Emerging Biological Applications
TL;DR: This review elucidate FGNs-bioorganism interactions and summarize recent advancements on designing FGN-based two-dimensional and three-dimensional architectures as multifunctional biological platforms.
Journal ArticleDOI
Safety assessment of graphene-based materials: focus on human health and the environment
Bengt Fadeel,Cyrill Bussy,Sonia Merino,Ester Vázquez,Emmanuel Flahaut,Florence Mouchet,Lauris Evariste,Laury Gauthier,Antti Joonas Koivisto,Ulla Vogel,Cristina Martín,Lucia Gemma Delogu,Tina Buerki-Thurnherr,Peter Wick,Didier Beloin-Saint-Pierre,Roland Hischier,Marco Pelin,Fabio Candotto Carniel,Mauro Tretiach,Fabrizia Cesca,Fabio Benfenati,Denis Scaini,Laura Ballerini,Kostas Kostarelos,Maurizio Prato,Maurizio Prato,Alberto Bianco +26 more
TL;DR: In this paper, the authors discuss synthesis and characterization of GBMs as well as human and environmental hazard assessment of GBM using in vitro and in vivo model systems with the aim to understand the properties that underlie the biological effects of these materials; not all GBMs are alike, and it is essential that disentangle the structure-activity relationships for this class of materials.
Journal ArticleDOI
2D-Crystal-Based Functional Inks
TL;DR: The exfoliation strategies of graphite and other layered crystals are reviewed, along with the advances in the sorting of lateral size and thickness of the exfoliated sheets together with the formulation of functional inks and the current development of printing/coating processes of interest for the realization of 2D-crystal-based devices.
Production and processing of graphene and related materials
Claudia Backes,Claudia Backes,Amr M. Abdelkader,Concepción Alonso,Amandine Andrieux-Ledier,Raul Arenal,Raul Arenal,Jon Azpeitia,Nilanthy Balakrishnan,Luca Banszerus,Julien Barjon,Ruben Bartali,Sebastiano Bellani,Claire Berger,Claire Berger,Reinhard Berger,M.M. Bernal Ortega,Carlo Bernard,Peter H. Beton,André Beyer,Alberto Bianco,Peter Bøggild,Francesco Bonaccorso,Gabriela Borin Barin,Cristina Botas,Rebeca A. Bueno,Daniel Carriazo,Andres Castellanos-Gomez,Meganne Christian,Artur Ciesielski,Tymoteusz Ciuk,Matthew T. Cole,Jonathan N. Coleman,Camilla Coletti,Luigi Crema,Huanyao Cun,Daniela Dasler,Domenico De Fazio,Noel Díez,Simon Drieschner,Georg S. Duesberg,Roman Fasel,Roman Fasel,Xinliang Feng,Alberto Fina,Stiven Forti,Costas Galiotis,Costas Galiotis,Giovanni Garberoglio,Jorge M. Garcia,Jose A. Garrido,Marco Gibertini,Armin Gölzhäuser,Julio Gómez,Thomas Greber,Frank Hauke,Adrian Hemmi,Irene Hernández-Rodríguez,Andreas Hirsch,Stephen A. Hodge,Yves Huttel,Peter Uhd Jepsen,I. Jimenez,Ute Kaiser,Tommi Kaplas,HoKwon Kim,Andras Kis,Konstantinos Papagelis,Konstantinos Papagelis,Kostas Kostarelos,Aleksandra Krajewska,Kangho Lee,Changfeng Li,Harri Lipsanen,Andrea Liscio,Martin R. Lohe,Annick Loiseau,Lucia Lombardi,María Francisca López,Oliver Martin,Cristina Martín,Lidia Martínez,José A. Martín-Gago,José I. Martínez,Nicola Marzari,Alvaro Mayoral,Alvaro Mayoral,John B. McManus,Manuela Melucci,Javier Méndez,Cesar Merino,Pablo Merino,Andreas Meyer,Elisa Miniussi,Vaidotas Miseikis,Neeraj Mishra,Vittorio Morandi,Carmen Munuera,Roberto Muñoz,Hugo Nolan,Luca Ortolani,A. K. Ott,A. K. Ott,Irene Palacio,Vincenzo Palermo,John Parthenios,Iwona Pasternak,Amalia Patanè,Maurizio Prato,Maurizio Prato,Henri Prevost,Vladimir Prudkovskiy,Nicola M. Pugno,Nicola M. Pugno,Nicola M. Pugno,Teófilo Rojo,Antonio Rossi,Pascal Ruffieux,Paolo Samorì,Léonard Schué,Eki J. Setijadi,Thomas Seyller,Giorgio Speranza,Christoph Stampfer,I. Stenger,Wlodek Strupinski,Yuri Svirko,Simone Taioli,Simone Taioli,Kenneth B. K. Teo,Matteo Testi,Flavia Tomarchio,Mauro Tortello,Emanuele Treossi,Andrey Turchanin,Ester Vázquez,Elvira Villaro,Patrick Rebsdorf Whelan,Zhenyuan Xia,Rositza Yakimova,Sheng Yang,G. Reza Yazdi,Chanyoung Yim,Duhee Yoon,Xianghui Zhang,Xiaodong Zhuang,Luigi Colombo,Andrea C. Ferrari,Mar García-Hernández +148 more
TL;DR: In this article, the authors present an overview of the main techniques for production and processing of graphene and related materials (GRMs), as well as the key characterization procedures, adopting a 'hands-on' approach, providing practical details and procedures as derived from literature and from the authors' experience, in order to enable the reader to reproduce the results.
References
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Journal ArticleDOI
The rise of graphene
TL;DR: Owing to its unusual electronic spectrum, graphene has led to the emergence of a new paradigm of 'relativistic' condensed-matter physics, where quantum relativistic phenomena can now be mimicked and tested in table-top experiments.
Journal ArticleDOI
Raman spectrum of graphene and graphene layers.
Andrea C. Ferrari,Jannik C. Meyer,Vittorio Scardaci,Cinzia Casiraghi,Michele Lazzeri,Francesco Mauri,S. Piscanec,Da Jiang,K. S. Novoselov,S. Roth,A. K. Geim +10 more
TL;DR: This work shows that graphene's electronic structure is captured in its Raman spectrum that clearly evolves with the number of layers, and allows unambiguous, high-throughput, nondestructive identification of graphene layers, which is critically lacking in this emerging research area.
Journal ArticleDOI
Interpretation of Raman spectra of disordered and amorphous carbon
Andrea C. Ferrari,John Robertson +1 more
TL;DR: In this paper, a model and theoretical understanding of the Raman spectra in disordered and amorphous carbon is given, and the nature of the G and D vibration modes in graphite is analyzed in terms of the resonant excitation of \ensuremath{\pi} states and the long-range polarizability of the long range bonding.
Journal ArticleDOI
Large-Area Synthesis of High-Quality and Uniform Graphene Films on Copper Foils
Xuesong Li,Weiwei Cai,Jinho An,Seyoung Kim,Junghyo Nah,Dongxing Yang,Richard D. Piner,Aruna Velamakanni,Inhwa Jung,Emanuel Tutuc,Sanjay K. Banerjee,Luigi Colombo,Rodney S. Ruoff +12 more
TL;DR: It is shown that graphene grows in a self-limiting way on copper films as large-area sheets (one square centimeter) from methane through a chemical vapor deposition process, and graphene film transfer processes to arbitrary substrates showed electron mobilities as high as 4050 square centimeters per volt per second at room temperature.