Is Alzheimer's disease a Type 3 Diabetes? A critical appraisal.
TLDR
Significant shared mechanisms between AD and diabetes are discussed and therapeutic avenues for diabetes and AD are provided and the effects of insulin in the pathology of AD through cellular and molecular mechanisms are provided.About:
This article is published in Biochimica et Biophysica Acta.The article was published on 2017-05-01 and is currently open access. It has received 376 citations till now. The article focuses on the topics: Insulin resistance & Insulin.read more
Citations
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Journal ArticleDOI
Oxidative Stress, Synaptic Dysfunction, and Alzheimer’s Disease
Eric Tönnies,Eugenia Trushina +1 more
TL;DR: The role of oxidative stress in synaptic dysfunction in AD, innovative therapeutic strategies evolved based on a better understanding of the complexity of molecular mechanisms of AD, and the dual role ROS play in health and disease are discussed.
Journal ArticleDOI
Melatonin and inflammation—Story of a double‐edged blade
TL;DR: A particular role in melatonin's actions seems to be associated with the upregulation of sirtuin‐1 (SIRT1), which shares various effects known from melatonin and additionally interferes with the signaling by the mechanistic target of rapamycin and Notch, and reduces the expression of the proinflammatory lncRNA‐CCL2.
Journal ArticleDOI
Obesity pandemic: causes, consequences, and solutions—but do we have the will?
TL;DR: The many causes of obesity are described, including key roles that a dysbiotic intestinal microbiome plays in metabolic derangements accompanying obesity, increased calorie absorption, and increased appetite and fat storage.
Journal ArticleDOI
Nutrient regulation of signaling and transcription.
TL;DR: This review will present an overview of the current understanding of O-GlcNAc's regulation, functions, and roles in chronic diseases of aging.
Journal ArticleDOI
Comprehensive review of mechanisms of pathogenesis involved in Alzheimer's disease and potential therapeutic strategies.
Piyoosh Sharma,Pavan Srivastava,Ankit Seth,Prabhash Nath Tripathi,Anupam G. Banerjee,Sushant K. Shrivastava +5 more
TL;DR: The present review provides an insight to the different molecular mechanisms involved in the development and progression of the AD and potential therapeutic strategies, enlightening perceptions into structural information of conventional and novel targets along with the successful applications of computational approaches for the design of target-specific inhibitors.
References
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Journal ArticleDOI
Insulin resistance and Alzheimer-like reductions in regional cerebral glucose metabolism for cognitively normal adults with prediabetes or early type 2 diabetes.
Laura D. Baker,Donna J. Cross,Satoshi Minoshima,Dana Belongia,G. Stennis Watson,Suzanne Craft +5 more
TL;DR: Greater insulin resistance was associated with an AD-like pattern of reduced CMRglu in frontal, parietotemporal, and cingulate regions in adults with PD/T2D.
Journal ArticleDOI
Cerebrospinal fluid and plasma insulin levels in Alzheimer's disease: relationship to severity of dementia and apolipoprotein E genotype.
Suzanne Craft,Elaine R. Peskind,Michael W. Schwartz,Gerard D. Schellenberg,Murray A. Raskind,Daniel Porte +5 more
TL;DR: Patients with Alzheimer's disease have elevations of fasting plasma insulin that are hypothesized to be associated with disrupted brain insulin metabolism, and there are metabolic differences among apolipoprotein E genotypes.
Journal ArticleDOI
Review of insulin and insulin-like growth factor expression, signaling, and malfunction in the central nervous system: relevance to Alzheimer's disease.
TL;DR: There is a genuine need for thorough and comprehensive study of the neuropathological changes associated with diabetes mellitus, in the presence of superimposed AD or vascular dementia, and strategies for intervention may depend entirely upon whether the CNS disease processes are mediated by peripheral, central, or both types of insulin resistance.
Book ChapterDOI
Advanced glycosylation: chemistry, biology, and implications for diabetes and aging.
Richard Bucala,Anthony Cerami +1 more
TL;DR: Given the slow, progressive nature of AGE accumulation in vivo and the active cell-mediated processes that appear to be required for AGE removal, it is likely that the investigation of advanced glycosylation mechanisms will continue to provide insight into a variety of additional biological and pathological processes that are characterized by long-term, age-related, and degenerative changes.
Journal ArticleDOI
Is Type II Diabetes Associated With an Increased Risk of Cognitive Dysfunction?: A critical review of published studies
TL;DR: Findings are consistent with type II diabetes being associated with an increased risk of cognitive dysfunction, however, the widespread differences in methodology between the studies should lead to a cautious interpretation of their conclusions.
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