Is Alzheimer's disease a Type 3 Diabetes? A critical appraisal.
TLDR
Significant shared mechanisms between AD and diabetes are discussed and therapeutic avenues for diabetes and AD are provided and the effects of insulin in the pathology of AD through cellular and molecular mechanisms are provided.About:
This article is published in Biochimica et Biophysica Acta.The article was published on 2017-05-01 and is currently open access. It has received 376 citations till now. The article focuses on the topics: Insulin resistance & Insulin.read more
Citations
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Diabetes and Sarcopenic Obesity: Pathogenesis, Diagnosis, and Treatments.
TL;DR: This review consolidates and discusses the latest research in pathogenesis, diagnosis, and treatments of diabetes and sarcopenic obesity.
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Metabolism: A Novel Shared Link between Diabetes Mellitus and Alzheimer's Disease.
Yanan Sun,Cao Ma,Cao Ma,Hui Sun,Huan Wang,Wei Peng,Zibo Zhou,Hongwei Wang,Chenchen Pi,Yingai Shi,Xu He +10 more
TL;DR: It is concluded from the published literature that the body's diabetic status under certain circumstances such as metabolic abnormalities can increase the incidence of AD by affecting glucose transport to the brain and reducing glucose metabolism.
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Neuroinflammation in Alzheimer's Disease.
TL;DR: In this paper, the authors discuss some current ideas on processes in inflammaging that appear to drive the neurodegenerative process in Alzheimer's disease and summarize details on a few immunomodulatory strategies being developed to selectively target the detrimental aspects of neuroinflammation without affecting defense mechanisms against pathogens and tissue damage.
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Diabetes drugs in the fight against Alzheimer's disease.
TL;DR: In this article, a review from animal to human studies aims at responding to the reasons why drugs for diabetes may represent potential treatments for Alzheimer's disease (AD) in old age subjects.
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Metabolic signaling functions of ER-mitochondria contact sites: role in metabolic diseases
Emily Tubbs,Jennifer Rieusset +1 more
TL;DR: Recent studies that have revealed the importance of MAM in not only metabolic diseases but also in other pathologies with disrupted metabolism are discussed, shedding light on potential common molecular mechanisms and leading hopefully to novel treatment strategies.
References
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Anne Brunet,Azad Bonni,Michael J. Zigmond,Michael Z. Lin,Peter Juo,Linda Hu,Michael J. Anderson,Karen C. Arden,John Blenis,Michael E. Greenberg +9 more
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Interleukin-3-Induced Phosphorylation of BAD Through the Protein Kinase Akt
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