Is Alzheimer's disease a Type 3 Diabetes? A critical appraisal.
TLDR
Significant shared mechanisms between AD and diabetes are discussed and therapeutic avenues for diabetes and AD are provided and the effects of insulin in the pathology of AD through cellular and molecular mechanisms are provided.About:
This article is published in Biochimica et Biophysica Acta.The article was published on 2017-05-01 and is currently open access. It has received 376 citations till now. The article focuses on the topics: Insulin resistance & Insulin.read more
Citations
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MiR-702-5p ameliorates diabetic encephalopathy in db/db mice by regulating 12/15-LOX
Y. Tu,Qi Chen,Wenjia Guo,Pu Xiang,Hai-Hua Huang,Hui-Zhi Fei,Li Chen,Yang Yang,Zhe Peng,Chao Gu,Xiao-dan Tan,Xia Liu,Yi Lu,Rongchun Chen,Hong Wang,Ying Luo,Junqing Yang +16 more
TL;DR: In this article , the effect of miR-702-5p on diabetic encephalopathy and 12/15-LOX in the central nervous system (CNS) was investigated.
Journal ArticleDOI
Elevated Peripheral Brain-Derived Neurotrophic Factor Level Associated With Decreasing Insulin Secretion May Forecast Memory Dysfunction in Patients With Long-Term Type 2 Diabetes
TL;DR: Elevated peripheral BDNF level associated with declined islet function, when combined with its Val66Met polymorphism, may forecast memory dysfunction in patients with long-term T2DM.
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From Single- to Multi-organ-on-a-Chip System for Studying Metabolic Diseases
Minjeong Jang,Hong Nam Kim +1 more
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Targeting the liver in dementia and cognitive impairment: Dietary macronutrients and diabetic therapeutics
Nicholas H. Hunt,Devin Wahl,Lara J. Westwood,Glen P Lockwood,David G. Le Couteur,Victoria C. Cogger +5 more
TL;DR: In this paper , targeted hepatic delivery of diabetic medicines using nanotechnologies and titration of macronutrients to optimize hepatic energy metabolism is proposed to improve cognition and reduce symptoms of dementia.
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The Use of Anti-Diabetic Drugs in Alzheimer’s Disease, New Therapeutic Options and Future Perspective
TL;DR: It is concluded that antidiabetics have good potential to improve dementia, especially in earlier AD stages, however, many of the underlying intricate molecular pathways are still unclear and thus thorough future research is required.
References
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Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor
Anne Brunet,Azad Bonni,Michael J. Zigmond,Michael Z. Lin,Peter Juo,Linda Hu,Michael J. Anderson,Karen C. Arden,John Blenis,Michael E. Greenberg +9 more
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Diffusible, nonfibrillar ligands derived from Aβ1–42 are potent central nervous system neurotoxins
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TL;DR: It is hypothesized that impaired synaptic plasticity and associated memory dysfunction during early stage Alzheimer's disease and severe cellular degeneration and dementia during end stage could be caused by the biphasic impact of Abeta-derived diffusible ligands acting upon particular neural signal transduction pathways.
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Interleukin-3-Induced Phosphorylation of BAD Through the Protein Kinase Akt
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Synthesis and Function of 3-Phosphorylated Inositol Lipids
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TL;DR: This review is focused on the 3-phosphoinositide lipids, the synthesis of which is acutely triggered by extracellular stimuli, the enzymes responsible for their synthesis and metabolism, and their cell biological roles.
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