Is Alzheimer's disease a Type 3 Diabetes? A critical appraisal.
TLDR
Significant shared mechanisms between AD and diabetes are discussed and therapeutic avenues for diabetes and AD are provided and the effects of insulin in the pathology of AD through cellular and molecular mechanisms are provided.About:
This article is published in Biochimica et Biophysica Acta.The article was published on 2017-05-01 and is currently open access. It has received 376 citations till now. The article focuses on the topics: Insulin resistance & Insulin.read more
Citations
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Aluminium toxicosis: a review of toxic actions and effects
TL;DR: A broad overview of Al toxicosis is provided as a background for sustained investigations of the toxicology of Al compounds of public health importance.
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Metformin – a Future Therapy for Neurodegenerative Diseases
Magdalena Markowicz-Piasecka,Joanna Sikora,Aleksandra Szydłowska,Agata Skupień,Elżbieta Mikiciuk-Olasik,Kristiina M. Huttunen +5 more
TL;DR: Results of several clinical studies confirm that long term use of metformin in diabetic patients contributes to better cognitive function, compared to participants using other anti-diabetic drugs.
Journal ArticleDOI
Clearance of cerebral Aβ in Alzheimer's disease: reassessing the role of microglia and monocytes.
TL;DR: The literature on cellular and molecular mechanisms of cerebral Aβ clearance with an emphasis on the role of peripheral monocytes and macrophages in Aβ removal is summarized and a new, unexpected role for peripheral monocyte andmacrophage role is highlighted in restricting cerebral A β fibrils, and possibly soluble oligomers.
Journal ArticleDOI
Targeting Neuroinflammation to Treat Alzheimer’s Disease
A. Ardura-Fabregat,Erik Boddeke,Antonio Boza-Serrano,S. Brioschi,Sergio Castro-Gomez,K. Ceyzériat,K. Ceyzériat,Cira Dansokho,T. Dierkes,T. Dierkes,Géraldine Gelders,Michael T. Heneka,Michael T. Heneka,Lianne Hoeijmakers,A. Hoffmann,Leonardo Iaccarino,S. Jahnert,K. Kuhbandner,Gary E. Landreth,Niklas Lonnemann,Peter-Andreas Löschmann,Róisín M. McManus,Agnes Paulus,Kitty Reemst,J. M. Sanchez-Caro,A. Tiberi,A. Van der Perren,A. Vautheny,A. Vautheny,Carmen Venegas,A. Webers,Patrick Weydt,Teodora Stella Wijasa,Xianyuan Xiang,Yiyi Yang +34 more
TL;DR: The principal cellular and molecular players in inflammation as they pertain to AD are described, modifying factors are examined, and potential future therapeutic targets are discussed.
Journal ArticleDOI
VDAC1, mitochondrial dysfunction, and Alzheimer's disease.
TL;DR: Targeting mitochondrial dysfunction via VDAC1, to prevent this pro‐apoptotic activity, could represent a novel strategy for inhibiting cell death.
References
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