Is Alzheimer's disease a Type 3 Diabetes? A critical appraisal.
TLDR
Significant shared mechanisms between AD and diabetes are discussed and therapeutic avenues for diabetes and AD are provided and the effects of insulin in the pathology of AD through cellular and molecular mechanisms are provided.About:
This article is published in Biochimica et Biophysica Acta.The article was published on 2017-05-01 and is currently open access. It has received 376 citations till now. The article focuses on the topics: Insulin resistance & Insulin.read more
Citations
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Oxidative Stress, Synaptic Dysfunction, and Alzheimer’s Disease
Eric Tönnies,Eugenia Trushina +1 more
TL;DR: The role of oxidative stress in synaptic dysfunction in AD, innovative therapeutic strategies evolved based on a better understanding of the complexity of molecular mechanisms of AD, and the dual role ROS play in health and disease are discussed.
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Melatonin and inflammation—Story of a double‐edged blade
TL;DR: A particular role in melatonin's actions seems to be associated with the upregulation of sirtuin‐1 (SIRT1), which shares various effects known from melatonin and additionally interferes with the signaling by the mechanistic target of rapamycin and Notch, and reduces the expression of the proinflammatory lncRNA‐CCL2.
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Obesity pandemic: causes, consequences, and solutions—but do we have the will?
TL;DR: The many causes of obesity are described, including key roles that a dysbiotic intestinal microbiome plays in metabolic derangements accompanying obesity, increased calorie absorption, and increased appetite and fat storage.
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Nutrient regulation of signaling and transcription.
TL;DR: This review will present an overview of the current understanding of O-GlcNAc's regulation, functions, and roles in chronic diseases of aging.
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Comprehensive review of mechanisms of pathogenesis involved in Alzheimer's disease and potential therapeutic strategies.
Piyoosh Sharma,Pavan Srivastava,Ankit Seth,Prabhash Nath Tripathi,Anupam G. Banerjee,Sushant K. Shrivastava +5 more
TL;DR: The present review provides an insight to the different molecular mechanisms involved in the development and progression of the AD and potential therapeutic strategies, enlightening perceptions into structural information of conventional and novel targets along with the successful applications of computational approaches for the design of target-specific inhibitors.
References
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Journal ArticleDOI
Intranasal insulin improves cognition and modulates β-amyloid in early AD
Mark A. Reger,G. S. Watson,Pattie S. Green,Charles W. Wilkinson,Laura D. Baker,Brenna Cholerton,Mark A. Fishel,S. R. Plymate,John C.S. Breitner,William DeGroodt,P. Mehta,P. Mehta,Suzanne Craft +12 more
TL;DR: The results of this pilot study support further investigation of the benefits of intranasal insulin for patients with Alzheimer disease, and suggest that intran asal peptide administration may be a novel approach to the treatment of neurodegenerative disorders.
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Regulation of AMPA Receptor–Mediated Synaptic Transmission by Clathrin-Dependent Receptor Internalization
Heng-Ye Man,Jerry W. Lin,William Ju,Gholamreza Ahmadian,Lidong Liu,Laurence E. Becker,Morgan Sheng,Yu Tian Wang +7 more
TL;DR: It is shown that AMPA receptors underwent clathrin-dependent endocytosis, which was accelerated by insulin in a GluR2 subunit-dependent manner, resulting in long-term depression of AMPA receptor-mediated synaptic transmission in hippocampal CA1 neurons.
Journal ArticleDOI
An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer’s disease–associated Aβ oligomers
Theresa R. Bomfim,Leticia Forny-Germano,Luciana B. Sathler,Jordano Brito-Moreira,Jean-Christophe Houzel,Helena Decker,Helena Decker,Michael A. Silverman,Hala Kazi,Helen M. Melo,Paula McClean,Christian Hölscher,Steven E. Arnold,Konrad Talbot,William L. Klein,Douglas P. Munoz,Sergio T. Ferreira,Fernanda G. De Felice +17 more
TL;DR: It is shown that serine phosphorylation of IRS-1 (IRS-1pSer) is common to both diseases, and establishes molecular links between the dysregulated insulin signaling in AD and diabetes.
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The prosurvival Bcl-2 homolog Bfl-1/A1 is a direct transcriptional target of NF-κB that blocks TNFα-induced apoptosis
TL;DR: It is demonstrated that the pro-survival Bcl-2 homolog Bfl-1/A1 is a direct transcriptional target of NF-kB and that it can substitute forNF-kB to suppress TNFa-induced apoptosis.
Journal ArticleDOI
Apolipoprotein E and Alzheimer disease
TL;DR: The identification of apoE in the cytoplasm of human neurons and the characterization of isoform-specific binding of apolipoprotein E to the microtubule-associated proteins tau and MAP-2 present the possibility that ApoE may affect microtubules function in the Alzheimer brain.
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