Is Alzheimer's disease a Type 3 Diabetes? A critical appraisal.
TLDR
Significant shared mechanisms between AD and diabetes are discussed and therapeutic avenues for diabetes and AD are provided and the effects of insulin in the pathology of AD through cellular and molecular mechanisms are provided.About:
This article is published in Biochimica et Biophysica Acta.The article was published on 2017-05-01 and is currently open access. It has received 376 citations till now. The article focuses on the topics: Insulin resistance & Insulin.read more
Citations
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Transcriptomic Downregulation of APOE, Polymorphic Variations of APOE, Diet, Social Isolation, and Co-morbidities as Contributing Factors to Alzheimer's Disease: a Case-Control Study of Kashmiri Population.
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The effect of adherence to screening guidelines on the risk of alzheimer’s disease in elderly individuals newly diagnosed with diabetes mellitus
TL;DR: Risk of Alzheimer’s disease can be reduced by behavioral factors, and possible mechanisms may include earlier start of interventions to reduce blood glucose levels and improve insulin sensitivity.
Journal ArticleDOI
Effect of involuntary and voluntary exercise in an enrichment environment on astrogliosis reaction of hippocampus white matter in type 3 diabetic rat models
TL;DR: In this paper , the authors used the Morris water maze test to evaluate spatial memory and learning of animals and found that the healthy control and sham groups spent more significant time in the target area than the type-3 diabetic group, but this difference was not statistically significant.
Posted ContentDOI
Screening for differentially expressed memory genes on a diabetes model induced by high sugar diet in Drosophila melanogaster: potential players for memory deficits
TL;DR: In this paper , a high-sugar diet (HSD) was fed to Drosophila melanogaster to mimic Type Two Diabetes mellitus (T2DM) to investigate its effects on memory as well as identify potential molecular players associated with the memory deficits induced by HSD.
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Discovery of a novel OGT inhibitor through high-throughput screening based on Homogeneous Time-Resolved Fluorescence (HTRF).
Xinyu Wu,Mingchen Wang,Yu-Chen Cao,Ying Xu,Ziqun Yang,Yiluan Ding,Jing Lu,Jie Zheng,Cheng Luo,Kehao Zhao,Shijie Chen +10 more
TL;DR: In this paper , the authors have developed and optimized a sensitive Homogeneous Time-Resolved Fluorescence (HTRF) assay then identified a novel OGT inhibitor CDDO (also called Bardoxolone) through a high-throughput screening (HTS) based on HTRF assay.
References
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Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor
Anne Brunet,Azad Bonni,Michael J. Zigmond,Michael Z. Lin,Peter Juo,Linda Hu,Michael J. Anderson,Karen C. Arden,John Blenis,Michael E. Greenberg +9 more
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Diffusible, nonfibrillar ligands derived from Aβ1–42 are potent central nervous system neurotoxins
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TL;DR: This review is focused on the 3-phosphoinositide lipids, the synthesis of which is acutely triggered by extracellular stimuli, the enzymes responsible for their synthesis and metabolism, and their cell biological roles.
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