Is Alzheimer's disease a Type 3 Diabetes? A critical appraisal.
TLDR
Significant shared mechanisms between AD and diabetes are discussed and therapeutic avenues for diabetes and AD are provided and the effects of insulin in the pathology of AD through cellular and molecular mechanisms are provided.About:
This article is published in Biochimica et Biophysica Acta.The article was published on 2017-05-01 and is currently open access. It has received 376 citations till now. The article focuses on the topics: Insulin resistance & Insulin.read more
Citations
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Oxidative Stress, Synaptic Dysfunction, and Alzheimer’s Disease
Eric Tönnies,Eugenia Trushina +1 more
TL;DR: The role of oxidative stress in synaptic dysfunction in AD, innovative therapeutic strategies evolved based on a better understanding of the complexity of molecular mechanisms of AD, and the dual role ROS play in health and disease are discussed.
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Melatonin and inflammation—Story of a double‐edged blade
TL;DR: A particular role in melatonin's actions seems to be associated with the upregulation of sirtuin‐1 (SIRT1), which shares various effects known from melatonin and additionally interferes with the signaling by the mechanistic target of rapamycin and Notch, and reduces the expression of the proinflammatory lncRNA‐CCL2.
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Obesity pandemic: causes, consequences, and solutions—but do we have the will?
TL;DR: The many causes of obesity are described, including key roles that a dysbiotic intestinal microbiome plays in metabolic derangements accompanying obesity, increased calorie absorption, and increased appetite and fat storage.
Journal ArticleDOI
Nutrient regulation of signaling and transcription.
TL;DR: This review will present an overview of the current understanding of O-GlcNAc's regulation, functions, and roles in chronic diseases of aging.
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Comprehensive review of mechanisms of pathogenesis involved in Alzheimer's disease and potential therapeutic strategies.
Piyoosh Sharma,Pavan Srivastava,Ankit Seth,Prabhash Nath Tripathi,Anupam G. Banerjee,Sushant K. Shrivastava +5 more
TL;DR: The present review provides an insight to the different molecular mechanisms involved in the development and progression of the AD and potential therapeutic strategies, enlightening perceptions into structural information of conventional and novel targets along with the successful applications of computational approaches for the design of target-specific inhibitors.
References
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Journal ArticleDOI
Signaling pathways: the benefits of good communication.
Tracey L. Fisher,Morris F. White +1 more
TL;DR: This crosstalk reveals how hyperactivated mTOR may suppress metastasis locally, while causing systemic insulin resistance that can progress to diabetes.
Journal ArticleDOI
Improved cognitive-cerebral function in older adults with chromium supplementation
TL;DR: It is suggested that supplementation with chromium picolinate can enhance cognitive inhibitory control and cerebral function in older adults at risk for neurodegeneration.
Journal ArticleDOI
Metabolic syndrome: a brain disease
Ram B. Singh,Siddharth Gupta,Parinita Dherange,Fabien De Meester,Agnieszka Wilczynska,Shaan E. Alam,Daniel Pella,Douglas W. Wilson +7 more
TL;DR: Treatment with ω-3 fatty acids may be applied for the prevention of metabolic syndrome, which is known to enhance parasympathetic activity and increase the secretion of anti-inflammatory cytokines interleukin (IL)-4 and IL-10 as well as acetylcholine in the hippocampus, may be protective.
Journal ArticleDOI
Insulin resistance, diabetes and cognitive function: Consequences for preventative strategies
TL;DR: The role of the metabolic syndrome in the risk of Alzheimer's disease is still a matter of debate as mentioned in this paper, and the possible mechanisms of cognitive alterations are multiple, and may differ according to age group and duration of diabetes or metabolic syndrome, and lifestyle interventions in middle-aged or younger-elderly subjects should also be implemented in the general population.
Journal ArticleDOI
Apo-E4 Allele in Conjunction with Aβ42 and Tau in CSF: Biomarker for Alzheimers Disease
Ramesh Kandimalla,Sudesh Prabhakar,B K Binukumar,Willayat Yousuf Wani,Nidhi Gupta,D. R. Sharma,Aditya Sunkaria,Vinod K. Grover,N. Bhardwaj,Kajal Jain,Kiran Dip Gill +10 more
TL;DR: Low Aβ42 and elevated tau concentrations in CSF may prove to be a better diagnostic marker for AD along with the Apo-E4 allele.
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