Is Alzheimer's disease a Type 3 Diabetes? A critical appraisal.
TLDR
Significant shared mechanisms between AD and diabetes are discussed and therapeutic avenues for diabetes and AD are provided and the effects of insulin in the pathology of AD through cellular and molecular mechanisms are provided.About:
This article is published in Biochimica et Biophysica Acta.The article was published on 2017-05-01 and is currently open access. It has received 376 citations till now. The article focuses on the topics: Insulin resistance & Insulin.read more
Citations
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Genetic Variation in Targets of Antidiabetic Drugs and Alzheimer Disease Risk
TL;DR: In this article , a 2-sample mendelian randomization study design was applied to examine the association between genetic variation in the targets of four antidiabetic drug classes and AD risk.
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The role of type 2 Diabetes mellitus as a risk factor for Alzheimer's and Parkinson's diseases
Kellen Rocha,Aline da Silva Goulart,Márcio Tavares Costa,Andréia Caroline Fernandes Salgueiro,Vanderlei Folmer +4 more
TL;DR: This study aimed to review the mechanisms associated with DM2 in the development of neurodegenerative diseases, such as Alzheimer's and Parkinson’s diseases.
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Glucose Metabolism is a Better Marker for Predicting Clinical Alzheimer’s Disease than Amyloid or Tau
Tyler C. Hammond,Ai-Ling Lin +1 more
TL;DR: Hammond et al. used an advanced statistical learning machine learning method, random forest, on data provided by the Alzheimer’s Disease Neuroimaging Initiative (ADNI) to measure the ability of beta-amyloid measured by positron emission tomography, phosphorylated tau measured in the cerebral spinal fluid, and structural imaging measured by magnetic resonance imaging to classify AD diagnosis.
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Mini review: The relationship between energy status and adult hippocampal neurogenesis
Taylor Landry,Hu Huang +1 more
TL;DR: The ability to generate new hippocampal neurons throughout adulthood and successfully integrate them into existing neural networks is critical to cognitive function, while disordered regulation of this process results in neurodegenerative or psychiatric disease.
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Dexibuprofen ameliorates peripheral and central risk factors associated with Alzheimer's disease in metabolically stressed APPswe/PS1dE9 mice.
Miren Ettcheto,Elena Sánchez-López,Amanda Cano,Marina Carrasco,Katherine Herrera,Patricia Regina Manzine,Triana Espinosa-Jiménez,Oriol Busquets,Ester Verdaguer,Jordi Olloquequi,Carme Auladell,Jaume Folch,Antoni Camins +12 more
TL;DR: Evidence suggest that chronic administration of dexibuprofen (DXI) prevents the progression of AD through the regulation of inflammation which contribute to improve hallmarks of this pathology.
References
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Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor
Anne Brunet,Azad Bonni,Michael J. Zigmond,Michael Z. Lin,Peter Juo,Linda Hu,Michael J. Anderson,Karen C. Arden,John Blenis,Michael E. Greenberg +9 more
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TL;DR: This review is focused on the 3-phosphoinositide lipids, the synthesis of which is acutely triggered by extracellular stimuli, the enzymes responsible for their synthesis and metabolism, and their cell biological roles.
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