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Open AccessJournal ArticleDOI

Is Alzheimer's disease a Type 3 Diabetes? A critical appraisal.

Ramesh Kandimalla, +2 more
- 01 May 2017 - 
- Vol. 1863, Iss: 5, pp 1078-1089
TLDR
Significant shared mechanisms between AD and diabetes are discussed and therapeutic avenues for diabetes and AD are provided and the effects of insulin in the pathology of AD through cellular and molecular mechanisms are provided.
About: 
This article is published in Biochimica et Biophysica Acta.The article was published on 2017-05-01 and is currently open access. It has received 376 citations till now. The article focuses on the topics: Insulin resistance & Insulin.

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Citations
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Journal ArticleDOI

Assessment of the Phenolic Profiles, Hypoglycemic Activity, and Molecular Mechanism of Different Highland Barley (Hordeum vulgare L.) Varieties.

Na Deng, +3 more
- 11 Feb 2020 - 
TL;DR: Highland barley phenolics could inhibit gluconeogenesis and motivate glycogen synthesis via down-regulating the gene expression of G6Pase, PEPCK, and glycogen synthase kinase 3β (GSK3β), while activating the expression of insulin receptor substrate-1 (IRS-1), phosphatidylinositol 3 kinase (PI3K), serine/threonine kinase
Journal ArticleDOI

Gut microbiota in dementia. Critical review of novel findings and their potential application.

Mateusz Łuc, +7 more
- 10 Jan 2021 - 
TL;DR: Taking advantage of the metabolic effects of cold exposure on organisms by the introduction of whole-body cryostimulation in dementia patients could lead to alterations in gut microbiota and, therefore, decrease of an inflammatory response and insulin resistance, which remain one of the critical metabolic features of dementia.
Journal ArticleDOI

The Implication of the Brain Insulin Receptor in Late Onset Alzheimer's Disease Dementia.

Jaume Folch, +13 more
- 29 Jan 2018 - 
TL;DR: The existing evidence supporting the concept that brain insulin resistance and altered glucose metabolism play an important role in pathogenesis of LOAD is discussed, and treatment approaches targeting insulin signalling using anti-diabetic drugs and mTOR inhibitors are discussed.
Journal ArticleDOI

Etiology of type 2 diabetes and Alzheimer's disease: Exploring the mitochondria.

Talisa K. Silzer, +1 more
- 18 Apr 2018 - 
TL;DR: It is posited that mitochondrial dysfunction lies at the root of the affected processes rather than alongside them as a co-pathology, and the role that mitochondria dysfunction plays in the shared pathophysiology.
Journal ArticleDOI

Effects of Propolis Extract and Propolis-Derived Compounds on Obesity and Diabetes: Knowledge from Cellular and Animal Models.

Hiroshi Kitamura
- 01 Dec 2019 - 
TL;DR: Accumulating evidence suggests that propolis extracts have therapeutic effects on obesity by controlling adipogenesis, adipokine secretion, food intake, and energy expenditure and that propoli treatment may mitigate diabetic complications such as nephropathy, retinopathy, foot ulcers, and non-alcoholic fatty liver disease.
References
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Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor

Anne Brunet, +9 more
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Diffusible, nonfibrillar ligands derived from Aβ1–42 are potent central nervous system neurotoxins

Mary P. Lambert, +14 more
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TL;DR: It is hypothesized that impaired synaptic plasticity and associated memory dysfunction during early stage Alzheimer's disease and severe cellular degeneration and dementia during end stage could be caused by the biphasic impact of Abeta-derived diffusible ligands acting upon particular neural signal transduction pathways.
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Journal ArticleDOI

Synthesis and Function of 3-Phosphorylated Inositol Lipids

Bart Vanhaesebroeck, +8 more
- 01 Jan 2001 - 
TL;DR: This review is focused on the 3-phosphoinositide lipids, the synthesis of which is acutely triggered by extracellular stimuli, the enzymes responsible for their synthesis and metabolism, and their cell biological roles.
Related Papers (5)

Alzheimer's Disease is Type 3 Diabetes—Evidence Reviewed

Suzanne M. de la Monte, +1 more
- 01 Nov 2008 - 

Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

Konrad Talbot, +15 more
- 02 Apr 2012 - 

Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease--is this type 3 diabetes?

Eric J. Steen, +8 more
- 01 Jan 2005 - 

Neuroinflammation in Alzheimer's disease

Michael T. Heneka, +41 more
- 01 Apr 2015 - 

Brain insulin resistance in type 2 diabetes and Alzheimer disease: concepts and conundrums

Steven E. Arnold, +11 more
- 29 Jan 2018 -