Is Alzheimer's disease a Type 3 Diabetes? A critical appraisal.
TLDR
Significant shared mechanisms between AD and diabetes are discussed and therapeutic avenues for diabetes and AD are provided and the effects of insulin in the pathology of AD through cellular and molecular mechanisms are provided.About:
This article is published in Biochimica et Biophysica Acta.The article was published on 2017-05-01 and is currently open access. It has received 376 citations till now. The article focuses on the topics: Insulin resistance & Insulin.read more
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Oxidative Stress, Synaptic Dysfunction, and Alzheimer’s Disease
Eric Tönnies,Eugenia Trushina +1 more
TL;DR: The role of oxidative stress in synaptic dysfunction in AD, innovative therapeutic strategies evolved based on a better understanding of the complexity of molecular mechanisms of AD, and the dual role ROS play in health and disease are discussed.
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Melatonin and inflammation—Story of a double‐edged blade
TL;DR: A particular role in melatonin's actions seems to be associated with the upregulation of sirtuin‐1 (SIRT1), which shares various effects known from melatonin and additionally interferes with the signaling by the mechanistic target of rapamycin and Notch, and reduces the expression of the proinflammatory lncRNA‐CCL2.
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Obesity pandemic: causes, consequences, and solutions—but do we have the will?
TL;DR: The many causes of obesity are described, including key roles that a dysbiotic intestinal microbiome plays in metabolic derangements accompanying obesity, increased calorie absorption, and increased appetite and fat storage.
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Nutrient regulation of signaling and transcription.
TL;DR: This review will present an overview of the current understanding of O-GlcNAc's regulation, functions, and roles in chronic diseases of aging.
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Comprehensive review of mechanisms of pathogenesis involved in Alzheimer's disease and potential therapeutic strategies.
Piyoosh Sharma,Pavan Srivastava,Ankit Seth,Prabhash Nath Tripathi,Anupam G. Banerjee,Sushant K. Shrivastava +5 more
TL;DR: The present review provides an insight to the different molecular mechanisms involved in the development and progression of the AD and potential therapeutic strategies, enlightening perceptions into structural information of conventional and novel targets along with the successful applications of computational approaches for the design of target-specific inhibitors.
References
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Fasting insulin and incident dementia in an elderly population of Japanese-American men.
TL;DR: Low and high levels of insulin are associated with an increased risk of developing dementia in a cohort of elderly men.
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Molecular connexions between dementia and diabetes
TL;DR: This review primarily focuses on the proposed molecular links between insulin action, Diabetes and Alzheimer's disease, while discussing the potential for therapeutic intervention to alleviate these disorders.
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The roles of inflammation and immune mechanisms in Alzheimer's disease.
Linda J. Van Eldik,Maria C. Carrillo,Patricia E. Cole,Dominik Feuerbach,Barry D. Greenberg,James Hendrix,Matthew E. Kennedy,Nick Kozauer,Richard Margolin,José Luis Molinuevo,José Luis Molinuevo,Reinhold Mueller,Richard M. Ransohoff,Donna M. Wilcock,Lisa J. Bain,Kelly R. Bales +15 more
TL;DR: The Alzheimer's Association's Research roundtable met in April 2015 to explore the role of neuroinflammatory mechanisms in the progression of Alzheimer's disease and important challenges impeding the advancement of new therapeutic agents and strategies to overcome them.
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Insulin and insulin-like growth factor I enhance regeneration in cultured adult rat sensory neurones
TL;DR: In this article, the effects of insulin, IGF-I, NGF, and nerve growth factor (NGF) on regeneration and neuronal survival were studied in cultured adult rat sensory neurones in a cell culture environment that limited non-neuronal cell mediated effects.
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Amyloid-β oligomers link depressive-like behavior and cognitive deficits in mice
Jose Henrique Ledo,Estefania P. Azevedo,Julia R. Clarke,Felipe C. Ribeiro,Cláudia P. Figueiredo,Debora Foguel,F G De Felice,Sergio T. Ferreira +7 more
TL;DR: The results indicate that AβOs have an acute impact on memory, learning and mood in mice, and that fluoxetine treatment prevented both cognitive impairment and depressive-like behavior induced by A βOs.
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