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Open AccessJournal ArticleDOI

Is Alzheimer's disease a Type 3 Diabetes? A critical appraisal.

Ramesh Kandimalla, +2 more
- 01 May 2017 - 
- Vol. 1863, Iss: 5, pp 1078-1089
TLDR
Significant shared mechanisms between AD and diabetes are discussed and therapeutic avenues for diabetes and AD are provided and the effects of insulin in the pathology of AD through cellular and molecular mechanisms are provided.
About: 
This article is published in Biochimica et Biophysica Acta.The article was published on 2017-05-01 and is currently open access. It has received 376 citations till now. The article focuses on the topics: Insulin resistance & Insulin.

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Citations
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Journal ArticleDOI

Emerging role of amyloid beta in stress response: Implication for depression and diabetes.

Maria Grazia Morgese, +2 more
- 15 Dec 2017 - 
TL;DR: The main aim of the present review is to evaluate the most recent literature findings in humans and animal models in regard to the role of Aβ in stress response and in relation to the biological substrates and pathological pathways common to AD and comorbid diseases, such as depression and diabetes.
Journal ArticleDOI

Epigallocatechin-3-Gallate (EGCG) Improves Cognitive Deficits Aggravated by an Obesogenic Diet Through Modulation of Unfolded Protein Response in APPswe/PS1dE9 Mice

Miren Ettcheto, +11 more
- 01 Apr 2020 - 
TL;DR: Evidence suggests that chronic EGCG prevents distinct neuropathological AD-related hallmarks and may be a promising disease-modifying treatment for neurodegenerative diseases.

Targeting Neuroinflammation to Treat Alzheimer's Disease

A. Ardura-Fabregat, +34 more
TL;DR: A recent review as discussed by the authors provides an overview of the current understanding of AD-related immune processes, including the principal cellular and molecular players in inflammation as they pertain to AD, examine modifying factors, and discuss potential future therapeutic targets.
Journal ArticleDOI

Caveolin: A New Link Between Diabetes and AD.

Andrei Surguchov
- 23 Jan 2020 - 
TL;DR: Investigations indicate that caveolin-1 (CAV-1)—a small membrane protein involved in signaling pathways—may play an important role in this association between type 2 diabetes mellitus and Alzheimer’s disease, and preliminary results pointing to this role were collected after examination of patients with AD.
Journal ArticleDOI

Role of Insulin Resistance in the Alzheimer's Disease Progression.

Thuy Trang Nguyen, +4 more
- 20 Apr 2020 - 
TL;DR: The basic mechanisms of the insulin resistance mediates dysregulation of bioenergetics and progress to AD as a mechanistic link between diabetes mellitus and AD are demonstrated.
References
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Journal ArticleDOI

Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor

Anne Brunet, +9 more
- 19 Mar 1999 - 
TL;DR: It is demonstrated that Akt also regulates the activity of FKHRL1, a member of the Forkhead family of transcription factors, which triggers apoptosis most likely by inducing the expression of genes that are critical for cell death, such as the Fas ligand gene.
Journal ArticleDOI

Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery

Sandeep Robert Datta, +6 more
- 17 Oct 1997 - 
TL;DR: It is shown that growth factor activation of the PI3'K/Akt signaling pathway culminates in the phosphorylation of the BCL-2 family member BAD, thereby suppressing apoptosis and promoting cell survival.
Journal ArticleDOI

Diffusible, nonfibrillar ligands derived from Aβ1–42 are potent central nervous system neurotoxins

Mary P. Lambert, +14 more
- 26 May 1998 - 
TL;DR: It is hypothesized that impaired synaptic plasticity and associated memory dysfunction during early stage Alzheimer's disease and severe cellular degeneration and dementia during end stage could be caused by the biphasic impact of Abeta-derived diffusible ligands acting upon particular neural signal transduction pathways.
Journal ArticleDOI

Interleukin-3-Induced Phosphorylation of BAD Through the Protein Kinase Akt

Luis del Peso, +8 more
- 24 Oct 1997 - 
TL;DR: The proapoptotic function of BAD is regulated by the PI 3-kinase-Akt pathway, and active, but not inactive, forms of Akt were found to phosphorylate BAD in vivo and in vitro at the same residues that are phosphorylated in response to IL-3.
Journal ArticleDOI

Synthesis and Function of 3-Phosphorylated Inositol Lipids

Bart Vanhaesebroeck, +8 more
- 01 Jan 2001 - 
TL;DR: This review is focused on the 3-phosphoinositide lipids, the synthesis of which is acutely triggered by extracellular stimuli, the enzymes responsible for their synthesis and metabolism, and their cell biological roles.
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Alzheimer's Disease is Type 3 Diabetes—Evidence Reviewed

Suzanne M. de la Monte, +1 more
- 01 Nov 2008 - 

Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

Konrad Talbot, +15 more
- 02 Apr 2012 - 

Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease--is this type 3 diabetes?

Eric J. Steen, +8 more
- 01 Jan 2005 - 

Neuroinflammation in Alzheimer's disease

Michael T. Heneka, +41 more
- 01 Apr 2015 - 

Brain insulin resistance in type 2 diabetes and Alzheimer disease: concepts and conundrums

Steven E. Arnold, +11 more
- 29 Jan 2018 -