Is Alzheimer's disease a Type 3 Diabetes? A critical appraisal.
TLDR
Significant shared mechanisms between AD and diabetes are discussed and therapeutic avenues for diabetes and AD are provided and the effects of insulin in the pathology of AD through cellular and molecular mechanisms are provided.About:
This article is published in Biochimica et Biophysica Acta.The article was published on 2017-05-01 and is currently open access. It has received 376 citations till now. The article focuses on the topics: Insulin resistance & Insulin.read more
Citations
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Beyond amyloid: Immune, cerebrovascular, and metabolic contributions to Alzheimer disease in people with Down syndrome
TL;DR: In this article , the authors discuss evidence that multiple genes on chromosome 21 are associated with metabolic dysfunction in Down syndrome, leading to increased risk of Alzheimer disease (AD), presumably conferred through genetic predispositions arising from trisomy 21.
Journal ArticleDOI
Diabetic Theory in Anti-Alzheimer's Drug Research and Development - Part 1: Therapeutic Potential of Antidiabetic Agents.
TL;DR: The purpose of this review was to update the most recent reports on the discovery and development of antidiabetic agents as promising drugs for the symptomatic and disease-modifying treatment of AD.
Proceedings ArticleDOI
Functional near-infrared spectroscopy of prefrontal cortex during memory encoding and recall in elderly with type 2 diabetes mellitus
TL;DR: This study establishes forehead portable brain imaging under cognitive load for monitoring cerebrovascular function in T2DM and finds a significant difference in the PFC activation between elderly subjects with type 2 diabetes mellitus and age-matched elderly controls.
Journal ArticleDOI
Estradiol selectively regulates metabolic substrates across memory systems in models of menopause.
A. V. Prakapenka,Donna L. Korol +1 more
TL;DR: In this article, the authors proposed that regulation of neural metabolism is one likely mechanism for these bidirectional effects of estradiol on cognition, and they found that estrogens increased extracellular levels of glucose in the hippocampus, a shift that corresponds to the hormone's beneficial effects on hippocampus-sensitive cognition.
Journal ArticleDOI
Is Alzheimer's disease a type 3 diabetes? A review.
TL;DR: This is a review article that deals with the question of whether type 2 diabetes is a risk factor for the development of Alzheimer's disease, and some researches proposed the term "type 3 diabetes" for Alzheimer's Disease.
References
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Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor
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