Is Alzheimer's disease a Type 3 Diabetes? A critical appraisal.
TLDR
Significant shared mechanisms between AD and diabetes are discussed and therapeutic avenues for diabetes and AD are provided and the effects of insulin in the pathology of AD through cellular and molecular mechanisms are provided.About:
This article is published in Biochimica et Biophysica Acta.The article was published on 2017-05-01 and is currently open access. It has received 376 citations till now. The article focuses on the topics: Insulin resistance & Insulin.read more
Citations
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Journal ArticleDOI
Advanced Glycation End Products Modulate Amyloidogenic APP Processing and Tau Phosphorylation: A Mechanistic Link between Glycation and the Development of Alzheimer’s Disease
Kedar B. Batkulwar,Kedar B. Batkulwar,Rashmi K. Godbole,Reema Banarjee,Reema Banarjee,Omar Kassaar,Robert J. Williams,Mahesh J. Kulkarni,Mahesh J. Kulkarni +8 more
TL;DR: It is demonstrated that the AGE-RAGE axis regulates Aβ1-42 formation and tau phosphorylation via increased cathepsin B and AEP, providing a new molecular link between AGEs and AD pathology.
Journal ArticleDOI
The Impact of Disease Comorbidities in Alzheimer's Disease.
TL;DR: In this paper, the impact of the most common comorbidities in the clinical management of Alzheimer's disease patients is discussed, and some drugs commonly prescribed to patients with diabetes and cardiovascular disease have shown promising results in AD patients.
Journal ArticleDOI
Cold-induced lipid dynamics and transcriptional programs in white adipose tissue
TL;DR: TheCold-induced lipid dynamics and gene expression pathways in iWAT are contrary to those previously observed in metabolic syndrome, neurodegenerative disorders, and aging, suggesting beneficial effects of cold-induced WAT browning on health and lifespan.
Journal ArticleDOI
The cognitive control of eating and body weight: it's more than what you "think"
TL;DR: Evidence is reviewed that consuming a WD is associated with the emergence of pathophysiologies in the hippocampus, an important brain substrate for learning, memory, and cognition, and how eating a WD could impair hippocampal function, producing cognitive deficits that promote increased WD intake and body weight gain.
Journal ArticleDOI
Central insulin dysregulation and energy dyshomeostasis in two mouse models of Alzheimer's disease.
Ramon Velazquez,An Tran,Egide Ishimwe,Larry Denner,Nikhil Dave,Salvatore Oddo,Kelly T. Dineley +6 more
TL;DR: It is reported that CNS insulin signaling abnormalities are evident months before peripheral insulin resistance, and that brain energy metabolism is differentially altered in both mouse models, with 3xTg-AD mice showing more extensive changes.
References
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Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor
Anne Brunet,Azad Bonni,Michael J. Zigmond,Michael Z. Lin,Peter Juo,Linda Hu,Michael J. Anderson,Karen C. Arden,John Blenis,Michael E. Greenberg +9 more
TL;DR: It is demonstrated that Akt also regulates the activity of FKHRL1, a member of the Forkhead family of transcription factors, which triggers apoptosis most likely by inducing the expression of genes that are critical for cell death, such as the Fas ligand gene.
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Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery
Sandeep Robert Datta,Henryk Dudek,Xu Tao,Shane C. Masters,Haian Fu,Yukiko Gotoh,Michael E. Greenberg +6 more
TL;DR: It is shown that growth factor activation of the PI3'K/Akt signaling pathway culminates in the phosphorylation of the BCL-2 family member BAD, thereby suppressing apoptosis and promoting cell survival.
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Diffusible, nonfibrillar ligands derived from Aβ1–42 are potent central nervous system neurotoxins
Mary P. Lambert,A. K. Barlow,Brett A. Chromy,C. Edwards,R. Freed,M. Liosatos,Todd E. Morgan,Irina Rozovsky,Barbara L. Trommer,Kirsten L. Viola,Pat Wals,Chuan Zhang,Caleb E. Finch,Grant A. Krafft,William L. Klein +14 more
TL;DR: It is hypothesized that impaired synaptic plasticity and associated memory dysfunction during early stage Alzheimer's disease and severe cellular degeneration and dementia during end stage could be caused by the biphasic impact of Abeta-derived diffusible ligands acting upon particular neural signal transduction pathways.
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Interleukin-3-Induced Phosphorylation of BAD Through the Protein Kinase Akt
Luis del Peso,Maribel González-García,Maribel González-García,Carmen Page,Carmen Page,Roman Herrera,Roman Herrera,Gabriel Núñez,Gabriel Núñez +8 more
TL;DR: The proapoptotic function of BAD is regulated by the PI 3-kinase-Akt pathway, and active, but not inactive, forms of Akt were found to phosphorylate BAD in vivo and in vitro at the same residues that are phosphorylated in response to IL-3.
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Synthesis and Function of 3-Phosphorylated Inositol Lipids
Bart Vanhaesebroeck,Sally J. Leevers,Khatereh Ahmadi,John F. Timms,Roy Katso,Paul C. Driscoll,Rudiger Woscholski,Peter J. Parker,Michael D. Waterfield +8 more
TL;DR: This review is focused on the 3-phosphoinositide lipids, the synthesis of which is acutely triggered by extracellular stimuli, the enzymes responsible for their synthesis and metabolism, and their cell biological roles.
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