Is Alzheimer's disease a Type 3 Diabetes? A critical appraisal.
TLDR
Significant shared mechanisms between AD and diabetes are discussed and therapeutic avenues for diabetes and AD are provided and the effects of insulin in the pathology of AD through cellular and molecular mechanisms are provided.About:
This article is published in Biochimica et Biophysica Acta.The article was published on 2017-05-01 and is currently open access. It has received 376 citations till now. The article focuses on the topics: Insulin resistance & Insulin.read more
Citations
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Association between Parkinson’s Disease and Diabetes Mellitus: From Epidemiology, Pathophysiology and Prevention to Treatment
TL;DR: In this article , the epidemiological and pathophysiological association between DM and PD and summarize the antidiabetic drugs used in animal models and clinical trials of PD, which may provide reference for the clinical translation of antidisabetic drugs in PD treatment.
Book ChapterDOI
Bioactive Metabolites Isolated from Microorganisms for Healthcare: Types and Delivery Routes
TL;DR: There are reports suggesting that microbial metabolites are more reliable in terms of efficacy and potential when compared to its chemical counterparts for curing human diseases.
Journal ArticleDOI
Evaluation of Cognitive Impairment in Type 2 Diabetic Patients with Chronic Periodontitis: A Cross-sectional Study.
TL;DR: Cognitive impairment was found to coexist with HbA1c levels ≥7% and moderate-to-severe periodontitis in the elderly diabetics and adds opportunities to form disease modifiable areas in the Elderly diabetic population at a risk for the development of dementia.
Journal ArticleDOI
Disruption of Glucose Metabolism in Aged Octodon degus: A Sporadic Model of Alzheimer's Disease.
Pedro Cisternas,Camila Gherardelli,Paulina Salazar,Nibaldo C. Inestrosa,Nibaldo C. Inestrosa +4 more
TL;DR: In this paper, the authors measured several markers of glucose metabolism, namely, glucose uptake, ATP production, and glycolysis and pentose phosphate pathway (PPP) flux, in hippocampal slices from degus of different ages.
Journal ArticleDOI
Advances in PPARs Molecular Dynamics and Glitazones as a Repurposing Therapeutic Strategy through Mitochondrial Redox Dynamics against Neurodegeneration
TL;DR: In this article , a review of the role of peroxisome proliferator-activated receptors (PPARs) and their receptor isoforms in neural systems, and neurodegeneration in human beings is presented.
References
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Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor
Anne Brunet,Azad Bonni,Michael J. Zigmond,Michael Z. Lin,Peter Juo,Linda Hu,Michael J. Anderson,Karen C. Arden,John Blenis,Michael E. Greenberg +9 more
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Diffusible, nonfibrillar ligands derived from Aβ1–42 are potent central nervous system neurotoxins
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