Is Alzheimer's disease a Type 3 Diabetes? A critical appraisal.
TLDR
Significant shared mechanisms between AD and diabetes are discussed and therapeutic avenues for diabetes and AD are provided and the effects of insulin in the pathology of AD through cellular and molecular mechanisms are provided.About:
This article is published in Biochimica et Biophysica Acta.The article was published on 2017-05-01 and is currently open access. It has received 376 citations till now. The article focuses on the topics: Insulin resistance & Insulin.read more
Citations
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Oxidative Stress, Synaptic Dysfunction, and Alzheimer’s Disease
Eric Tönnies,Eugenia Trushina +1 more
TL;DR: The role of oxidative stress in synaptic dysfunction in AD, innovative therapeutic strategies evolved based on a better understanding of the complexity of molecular mechanisms of AD, and the dual role ROS play in health and disease are discussed.
Journal ArticleDOI
Melatonin and inflammation—Story of a double‐edged blade
TL;DR: A particular role in melatonin's actions seems to be associated with the upregulation of sirtuin‐1 (SIRT1), which shares various effects known from melatonin and additionally interferes with the signaling by the mechanistic target of rapamycin and Notch, and reduces the expression of the proinflammatory lncRNA‐CCL2.
Journal ArticleDOI
Obesity pandemic: causes, consequences, and solutions—but do we have the will?
TL;DR: The many causes of obesity are described, including key roles that a dysbiotic intestinal microbiome plays in metabolic derangements accompanying obesity, increased calorie absorption, and increased appetite and fat storage.
Journal ArticleDOI
Nutrient regulation of signaling and transcription.
TL;DR: This review will present an overview of the current understanding of O-GlcNAc's regulation, functions, and roles in chronic diseases of aging.
Journal ArticleDOI
Comprehensive review of mechanisms of pathogenesis involved in Alzheimer's disease and potential therapeutic strategies.
Piyoosh Sharma,Pavan Srivastava,Ankit Seth,Prabhash Nath Tripathi,Anupam G. Banerjee,Sushant K. Shrivastava +5 more
TL;DR: The present review provides an insight to the different molecular mechanisms involved in the development and progression of the AD and potential therapeutic strategies, enlightening perceptions into structural information of conventional and novel targets along with the successful applications of computational approaches for the design of target-specific inhibitors.
References
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CREB Is a Regulatory Target for the Protein Kinase Akt/PKB
Keyong Du,Marc Montminy +1 more
TL;DR: The results support the notion that Akt/PKB promotes cell survival, at least in part, by stimulating the expression of cellular genes via the CREB/CBP nuclear transduction pathway.
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Phosphoinositide 3-kinase : the key switch mechanism in insulin signalling
TL;DR: Using mechanisms such as this, PI 3-kinase is able to act as a molecular switch to regulate the activity of serine/threonine-specific kinase cascades important in mediating insulin's effects on endpoint responses.
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Synaptic Targeting by Alzheimer's-Related Amyloid β Oligomers
Pascale N. Lacor,Maria C. Buniel,Lei Chang,Sara J. Fernandez,Yuesong Gong,Kirsten L. Viola,Mary P. Lambert,Pauline T. Velasco,Eileen H. Bigio,Caleb E. Finch,Grant A. Krafft,William L. Klein +11 more
TL;DR: The hypothesis that targeting and functional disruption of particular synapses by Aβ oligomers may provide a molecular basis for the specific loss of memory function in early Alzheimer's disease is suggested.
Journal ArticleDOI
Functional brain abnormalities in young adults at genetic risk for late-onset Alzheimer's dementia
Eric M. Reiman,Kewei Chen,Gene E. Alexander,Gene E. Alexander,Richard J. Caselli,Richard J. Caselli,Daniel Bandy,David Osborne,David Osborne,Ann M. Saunders,Ann M. Saunders,John Hardy,John Hardy +12 more
TL;DR: Young ε4 carriers and noncarriers did not differ significantly in their sex, age, educational level, clinical ratings, or neuropsychological test scores, and an aggregate surface-projection map was generated that compared regional PET measurements in the two groups.
Journal ArticleDOI
Alzheimer's Disease is Type 3 Diabetes—Evidence Reviewed
TL;DR: The term “type 3 diabetes” accurately reflects the fact that AD represents a form of diabetes that selectively involves the brain and has molecular and biochemical features that overlap with both type 1 diabetes mellitus and T2DM.
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