Is Alzheimer's disease a Type 3 Diabetes? A critical appraisal.
TLDR
Significant shared mechanisms between AD and diabetes are discussed and therapeutic avenues for diabetes and AD are provided and the effects of insulin in the pathology of AD through cellular and molecular mechanisms are provided.About:
This article is published in Biochimica et Biophysica Acta.The article was published on 2017-05-01 and is currently open access. It has received 376 citations till now. The article focuses on the topics: Insulin resistance & Insulin.read more
Citations
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Journal ArticleDOI
Diagnostic Accuracy of Blood-Based Biomarker Panels: A Systematic Review
Anette Hardy-Sosa,Karen León-Arcia,Jorge J. Llibre-Guerra,Jorge Berlanga-Acosta,Saiyet de la C. Baez,Gerardo Guillén-Nieto,Pedro A. Valdes-Sosa +6 more
TL;DR: Assessment of Alzheimer’s disease biomarkers in blood as a non-invasive and cost-effective alternative will potentially contribute to early diagnosis and improvement of therapeutic interventions.
Journal ArticleDOI
Brain insulin resistance as a mechanistic mediator links peripheral metabolic disorders with declining cognition.
TL;DR: In this article , the role of brain insulin signaling and negative effect of dysmetabolism on insulin functioning in the brain was summarized. But, the authors focused on the negative effect on brain insulin functioning.
Journal ArticleDOI
High Plasma Resistin Levels Portend the Insulin Resistance-Associated Susceptibility to Early Cognitive Decline in Patients with Type 2 Diabetes Mellitus.
TL;DR: High plasma resistin levels portend the insulin resistance-related susceptibility to early cognitive decline in Chinese patients with type 2 diabetes mellitus and its clinical value for early disease screening must be further studied.
Book ChapterDOI
Neuroinflammation, microglial activation, and glucose metabolism in neurodegenerative diseases.
TL;DR: The way in which microglial activation influences neurodegeneration and how systemic inflammation, type 2 diabetes mellitus, obesity and hypercholesterolemia influence neuroinflammation are discussed.
Journal ArticleDOI
SLC2A3 rs12842 polymorphism and risk for Alzheimer's disease.
Stylianos Arseniou,Vasileios Siokas,Athina-Maria Aloizou,Polyxeni Stamati,Alexios-Fotios A. Mentis,Alexios-Fotios A. Mentis,Zisis Tsouris,Metaxia Dastamani,Eleni Peristeri,Varvara Valotassiou,Dimitrios P. Bogdanos,Georgios M. Hadjigeorgiou,Georgios M. Hadjigeorgiou,Efthimios Dardiotis +13 more
TL;DR: The results suggest a significant, inverse association between SLC2A3 rs12842 and the risk of AD.
References
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