Open Access
Phase solubility techniques
T K Higuchi,A Connors +1 more
- Vol. 4, pp 212-217
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The article was published on 1965-01-01 and is currently open access. It has received 2515 citations till now. The article focuses on the topics: Phase (matter) & Solubility.read more
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Study of the complexation behavior of tenoxicam with cyclodextrins in solution: improved solubility and percutaneous permeability.
TL;DR: The presence of MβCD improved the percutaneous penetration of TEN through abdominal rat skin by increasing the solubility of the drug in the vehicle and by affecting the partitioning behavior of T EN in the skin.
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A comprehensive study on the inclusion mechanism of benzophenone into supramolecular nanoassemblies prepared using two water-soluble associative polymers
TL;DR: In this paper, the entrapment of benzophenone (BZ) into supramolecular nanoassemblies prepared by mixing two water-soluble associative polymers (i.e. polymerized β-CD (pβ-CD) and dextran grafted with lauryl-side chains (MD)) was investigated by using isothermal titration microcalorimetry (ITC) and molecular modeling.
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γCD/HPγCD: Synergistic solubilization
TL;DR: Addition of 2-hydroxypropyl-gamma-cyclodextrin (HPgammaCD) to aqueous gammaCD solutions increases the complexation efficiency of gammaCD and reduces the turbidity, which makes it up to 50% more effective solubilizer for dexamethasone and hydrocortisone than expected.
Journal ArticleDOI
Study of omeprazole stability in aqueous solution: influence of cyclodextrins
TL;DR: In this paper, a stability indicating HPLC assay has been developed in order to investigate the effect of different factors on the stability of omeprazole, including pH and temperature.
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Physicochemical investigation of the solid dispersion systems of etoricoxib with poloxamer 188.
TL;DR: Solid dispersion systems of a poorly water-soluble drug, etoricoxib were prepared with poloxamer 188 in 1:0.5, 1:1.5 and 1:2.5 ratios suggesting optimum ratio of the carrier.