Open Access
Phase solubility techniques
T K Higuchi,A Connors +1 more
- Vol. 4, pp 212-217
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The article was published on 1965-01-01 and is currently open access. It has received 2515 citations till now. The article focuses on the topics: Phase (matter) & Solubility.read more
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Applications of steroid drugs entrapped in cyclodextrins
TL;DR: The effect of cyclodextrin–steroid interaction on the solubility, stability and bioavailability of the entrapped steroid drugs is highlighted, highlighting the importance of the catalysis and inhibition of various biotransformation reactions of steroids by cyclodesxtrin complexation used in biotechnology.
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Efficient Encapsulation of Citral in Fast-Dissolving Polymer-Free Electrospun Nanofibers of Cyclodextrin Inclusion Complexes: High Thermal Stability, Longer Shelf-Life, and Enhanced Water Solubility of Citral
TL;DR: Citral was efficiently encapsulated in citral/CD-IC-NFs, and these citrals have been shown to be fast dissolving and have enhanced water solubility of citral along with high-temperature stability and a longer shelf-life.
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An econazole β-cyclodextrin inclusion complex: an unusual dissolution rate, supersaturation, and biological efficacy example
Morten Pedersen,Simon Bjerregaard,Jette Bredahl Jacobsen,Annette Rômmelmayer Larsen,Alex Mehlsen Sørensen +4 more
TL;DR: Toxicity testing on a human buccal epithelium in vitro model — based on TR146 cells — showed that the physical mixture was more toxic than the inclusion complex when TR146 cell mortality was evaluated.
Journal ArticleDOI
Solubility of Clonazepam, Diazepam, Lamotrigine, and Phenobarbital in N-Methyl-2-pyrrolidone + Water Mixtures at 298.2 K
TL;DR: Experimental solubilities of clonazepam, diazepam, lamotrigine, and phenobarbital in binary solvent mixtures of N-methyl-2-pyrrolidone (NMP) + water at 298.2 K were reported.
Journal ArticleDOI
Hybrid liposomal PEGylated calix[4]arene systems as drug delivery platforms for curcumin.
Elena Drakalska,Denitsa Momekova,Yana Manolova,Dessislava Budurova,Georgi Momekov,Margarita Genova,Liudmil Antonov,Nikolay Lambov,Stanislav Rangelov +8 more
TL;DR: At concentrations exceeding the critical micellization concentration of PEGylated calixarene, the tremendous solubility enhancement of curcumin is attributed to additional solubilization and hydrophobic non-covalent interactions of the drug with supramolecular aggregates.